{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:38:12Z","timestamp":1788871092797,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,3,7]],"date-time":"2001-03-07T00:00:00Z","timestamp":983923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hungarian Council for Medical Sciences","award":["ETT 28\/2000"],"award-info":[{"award-number":["ETT 28\/2000"]}]},{"name":"National Science Foundation","award":["OTKA T 032270"],"award-info":[{"award-number":["OTKA T 032270"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effect of pH\n                    <jats:sub>o<\/jats:sub>\n                    on plasma membrane chloride current of cultured rat cortical astrocytes was investigated using the whole\u2010cell patch\u2010clamp technique. In the presence of intra\u2010 and extracellular solutions with symmetrical high Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    content and K\n                    <jats:sup>+<\/jats:sup>\n                    channel inhibitors, the cells exhibited an inwardly rectifying current. The current activated slowly at potentials negative to \u221240 mV and did not display time\u2010dependent inactivation. The current was inhibited by 0.1 mM Cd\n                    <jats:sup>2+<\/jats:sup>\n                    , 0.1 mM Zn\n                    <jats:sup>2+<\/jats:sup>\n                    , 1 mM 9\u2010anthracene\u2010carboxylic acid, and 0.2 mM 5\u2010nitro\u20102\u2010(3\u2010phenylpropylamino)benzoic acid, but not by 10 mM Ba\n                    <jats:sup>2+<\/jats:sup>\n                    or 3 mM Cs\n                    <jats:sup>+<\/jats:sup>\n                    . Reversal potential of the current followed the chloride equilibrium potential and was not influenced by changes in K\n                    <jats:sup>+<\/jats:sup>\n                    or Na\n                    <jats:sup>+<\/jats:sup>\n                    concentration. The inwardly rectifying chloride current was augmented by extracellular acidosis and reduced by alkalosis. The pH sensitivity was most pronounced in the physiologically relevant pH\n                    <jats:sub>o<\/jats:sub>\n                    range of 6.9\u20137.9. Lowering pH to 6.4 induced no additional increase in steady\u2010state current amplitude compared with pH\n                    <jats:sub>o<\/jats:sub>\n                    6.9, but it substantially slowed the activation kinetics. According to its kinetic and pharmacological properties this chloride current is similar to that found in cultured rat astrocytes after long\u2010term treatment with dibutyryl\u2010cAMP, however, in our cultures it was consistently expressed without any treatment with the drug. Considering that astrocytes possess carbonic anhydrase and Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    antiporter, this current may participate in the regulation of the interstitial and astrocyte pH. GLIA 34:52\u201358, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/glia.1039","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:27:27Z","timestamp":1030296447000},"page":"52-58","source":"Crossref","is-referenced-by-count":21,"title":["pH\u2010sensitive inwardly rectifying chloride current in cultured rat cortical astrocytes"],"prefix":"10.1002","volume":"34","author":[{"given":"Judit K.","family":"Makara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor 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