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Since recent studies have implicated glial cells in novel physiological roles in the CNS, such as modulation of synaptic transmission, it is plausible that glial cells may have a functional role in the hyperexcitability characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors and transporters have all been associated with the epileptic state. This review integrates the current evidence regarding astroglial dysfunction in epilepsy and the potential underlying mechanisms of hyperexcitability. Functional understanding of the cellular and molecular alterations of astroglia\u2010dependent hyperexcitability will help to clarify the physiological role of astrocytes in neural function as well as lead to the identification of novel therapeutic targets. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.20394","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T00:23:16Z","timestamp":1154564596000},"page":"358-368","source":"Crossref","is-referenced-by-count":271,"title":["Functional changes in astroglial cells in epilepsy"],"prefix":"10.1002","volume":"54","author":[{"given":"Devin 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