{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:41Z","timestamp":1762160621846},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T00:00:00Z","timestamp":1173744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apolipoprotein E (apoE) has immunomodulatory properties and has been implicated in the pathogenic mechanism of autoimmune diseases. Previously, the authors found that apoE deficiency increased the susceptibility to experimental autoimmune neuritis (EAN), an animal model for human Guillain\u2010Barr\u00e9 syndrome. To further elucidate the mechanism behind apoE deficiency exacerbating EAN, the authors investigated the role of major target and important antigen\u2010presenting cells of the peripheral nerve system, Schwann cells (SCs), in apoE knockout mice. Treatment of apoE deficient SCs with recombinant mouse interferon\u2010\u03b3 and lipopolysaccharide resulted in higher MHC\u2010II and CD40 expression as compared with normal SCs derived from wild\u2010type mice. The increased MHC\u2010II and CD40 expression on SCs was accompanied by lower levels of intracellular IL\u20106 production within SCs of apoE deficiency, which is confirmed by the neutralization with anti IL\u20106 antibody. The increased antigen\u2010presenting capacity of apoE deficient SCs was further explored by enhancement of T cell proliferation co\u2010cultured with P0 peptide 180\u2013199 specific T cells derived from EAN mice immunized with the P0 peptide. In conclusion, apoE may protect mice from EAN and probably also from chronic inflammatory demyelinating polyneuropathy by affecting the antigen\u2010presenting function of SCs via influence of IL\u20106 production. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.20498","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T22:15:05Z","timestamp":1173824105000},"page":"772-776","source":"Crossref","is-referenced-by-count":20,"title":["Apolipoprotein E deficiency enhances the antigen\u2010presenting capacity of Schwann cells"],"prefix":"10.1002","volume":"55","author":[{"given":"Rui\u2010Sheng","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eilhard","family":"Mix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdu","family":"Adem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90208-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130204"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83864-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.12.1484"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.3.312"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1995.1187"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830189809042997"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3463"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms950oa"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/513795"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32409-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.2.197"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00063-5"},{"key":"e_1_2_6_16_1","first-page":"2496s","article-title":"Suppression of lymphocyte activation by plasma lipoproteins","volume":"43","author":"Macy M","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3283935"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.3844"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210404"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(86)90059-7"},{"key":"e_1_2_6_21_1","first-page":"P03060","article-title":"The APOE 4 allele and progression of disability in multiple sclerosis","volume":"50","author":"Sylantiev C","year":"1998","journal-title":"Neurology"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01665.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(200006)30:4<373::AID-GLIA60>3.0.CO;2-#"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.2.120"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.20498","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.20498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T12:03:38Z","timestamp":1700049818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.20498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,13]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1002\/glia.20498"],"URL":"https:\/\/doi.org\/10.1002\/glia.20498","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,13]]}}}