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To gain insight into novel molecules that could mediate the OEC\u2010supported growth of axons within the olfactory nerve, gene expression profiling experiments were conducted which revealed high expression of the glycoprotein fibulin\u20103 in OECs. This observation was confirmed with quantitative PCR. <jats:italic>In vivo<\/jats:italic>, the distribution of all members of the fibulin family, fibulin\u20103 included, was localized to the lamina propria underneath the olfactory epithelium, in close association within olfactory nerve bundles. To manipulate fibulin\u20103 gene expression in cultured OECs, lentiviral vector constructs were designed to either transgenically express or knock\u2010down fibulin\u20103. Experimental data showed that increased levels of fibulin\u20103 induced profound morphological changes in cultured OECs, impeded with their migratory abilities and also suppressed OEC\u2010mediated neurite outgrowth. Knock\u2010down of fibulin\u20103 levels resulted in reduced OEC proliferation. In conclusion, the data provide novel insights into a putative role for fibulin\u20103 in the regulation of cell migration and neurite outgrowth within the primary olfactory pathway. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.20771","type":"journal-article","created":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T02:10:20Z","timestamp":1221876620000},"page":"424-443","source":"Crossref","is-referenced-by-count":42,"title":["The glycoprotein fibulin\u20103 regulates morphology and motility of olfactory ensheathing cells <i>in vitro<\/i>"],"prefix":"10.1002","volume":"57","author":[{"given":"Jana","family":"Vukovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc 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