{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:31:36Z","timestamp":1792125096901,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T00:00:00Z","timestamp":1224633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2009,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sustentacular cells have structural features that allude to functions of secretion, absorption, phagocytosis, maintenance of extracellular ionic gradients, metabolism of noxious chemicals, and regulation of cell turnover. We present data detailing their dynamic activity. We show, using a mouse olfactory epithelium slice model, that sustentacular cells are capable of generating two types of calcium signals: intercellular calcium waves where elevations in intracellular calcium propagate between neighboring cells, and intracellular calcium oscillations consisting of repetitive elevations in intracellular calcium confined to single cells. Sustentacular cells exhibited rapid, robust increases in intracellular calcium in response to G\u2010protein coupled muscarinic and purinergic receptor stimulation. In a subpopulation of sustentacular cells, oscillatory calcium transients were evoked. We pharmacologically characterized the properties of purinergic\u2010evoked increases in intracellular calcium. Calcium transients were elicited by release from intracellular stores and were not dependent on extracellular calcium. BAPTA\u2010AM, a cytosolic calcium chelator, and cyclopiazonic acid, an endoplasmic reticulum Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010ATPase inhibitor irreversibly blocked the purinergic\u2010induced calcium transient. Phospholipase C antagonist U73122 inhibited the purinergic\u2010evoked calcium transient. 2\u2010Aminoethoxydiphenyl borate, an inositol\u20101,4,5\u2010trisphosphate (IP\n                    <jats:sub>3<\/jats:sub>\n                    ) receptor antagonist, and the ryanodine receptor (RyR) antagonists tetracaine and ryanodine, inhibited the UTP\u2010induced calcium transients. Collectively, these data suggest that activation of the phospholipase C pathway, IP\n                    <jats:sub>3<\/jats:sub>\n                    \u2010mediated calcium release, and subsequent calcium\u2010induced\u2010calcium release is involved in ATP\u2010elicited increases in intracellular calcium. Our findings indicate that sustentacular cells are not static support cells, and, like glia in the central nervous system, have complex calcium signaling. \u00a9 2008 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/glia.20792","type":"journal-article","created":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T16:35:40Z","timestamp":1224693340000},"page":"634-644","source":"Crossref","is-referenced-by-count":75,"title":["Calcium store\u2010mediated signaling in sustentacular cells of the mouse olfactory epithelium"],"prefix":"10.1002","volume":"57","author":[{"given":"Colleen Cosgrove","family":"Hegg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mavis","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"Lucero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070230204"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-05-01792.2003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036035"},{"key":"e_1_2_5_5_1","first-page":"89","article-title":"Topological relations between the dendrites of olfactory sensory cells and sustentacular cells in different vertebrates. An ultrastructural study","volume":"117","author":"Breipohl W","year":"1974","journal-title":"J Anat"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90238-U"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(91)90020-F"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04533.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0989-5_3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7063870"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(90)90059-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04108.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-8-S3-S1"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90479-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1986.66.3.772"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35073601"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0429rev"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20714"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-23-08291.2003"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20258"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.1997.8.3-4.147"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440110211"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.10.1524"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.04.011"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.07.018"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90527-X"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1242\/jcs.89.4.495","article-title":"Tight\u2010junctional strands first appear in regions where three cells meet in differentiating olfactory epithelium: A freeze\u2010fracture study","volume":"89","author":"Menco BP","year":"1988","journal-title":"J Cell Sci"},{"key":"e_1_2_5_28_1","first-page":"17","volume-title":"Handbook of olfaction and gustation","author":"Menco BP","year":"2003"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903250304"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20030"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010711"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092060111"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11068-005-8360-2"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3250239"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03329.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19961223)376:4<509::AID-CNE1>3.0.CO;2-5"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(96)10048-5"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01299.2004"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079228"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.015"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01172-8"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03372-8"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.20792","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.20792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:44:03Z","timestamp":1697489043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.20792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,22]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,4,15]]}},"alternative-id":["10.1002\/glia.20792"],"URL":"https:\/\/doi.org\/10.1002\/glia.20792","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,22]]}}}