{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:51:14Z","timestamp":1772812274202,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T00:00:00Z","timestamp":1227139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Astrocytes participate in signaling via Ca<jats:sup>2+<\/jats:sup> transients that spread from cell to cell across a multicellular syncytium. The effect, if any, of these Ca<jats:sup>2+<\/jats:sup> waves on the transcription of Ca<jats:sup>2+<\/jats:sup>\/cAMP\u2010regulatory element binding protein (CREB)\u2010dependent genes is not known. We report here that, unlike neurons, increasing intracellular Ca<jats:sup>2+<\/jats:sup> in cultured mouse cortical astrocytes failed to activate CREB\u2010dependent transcription, even though CREB was phosphorylated at serine 133. In contrast, both CREB phosphorylation and CREB\u2010dependent transcription were robustly stimulated by increasing cAMP. The failure of Ca<jats:sup>2+<\/jats:sup>\u2010activated transcription in astrocytes was correlated with the absence of CaMKIV, a Ca<jats:sup>2+<\/jats:sup>\u2010dependent protein kinase required for Ca<jats:sup>2+<\/jats:sup>\u2010stimulated gene transcription in neurons. The inability of Ca<jats:sup>2+<\/jats:sup> to signal via CaMKIV may insulate CREB\u2010dependent gene transcription in astrocytes from activation by Ca<jats:sup>2+<\/jats:sup> waves. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.20809","type":"journal-article","created":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T22:30:22Z","timestamp":1227220222000},"page":"828-834","source":"Crossref","is-referenced-by-count":21,"title":["Failure of Ca<sup>2+<\/sup>\u2010activated, CREB\u2010dependent transcription in astrocytes"],"prefix":"10.1002","volume":"57","author":[{"given":"Peter D.","family":"Murray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami J.","family":"Kingsbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce K.","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199704)19:4<352::AID-GLIA8>3.0.CO;2-Z"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(99)00056-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81816-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10521"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4178-07.2008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20647"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90238-U"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5382.1505"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(90)90192-E"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1967852"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20464"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90131-V"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn835"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00654-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.10.032"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1054\/ceca.2001.0232"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303082200"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00828-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085068"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)83630-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.15.8629"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20374"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-22-08842.2001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.10.110194.000415"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.6.C1710"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.21.2527"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311844200"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00053-5"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501076102"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.20809","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.20809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:31:05Z","timestamp":1696894265000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.20809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,20]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/glia.20809"],"URL":"https:\/\/doi.org\/10.1002\/glia.20809","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,20]]}}}