{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:15:59Z","timestamp":1761488159436},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T00:00:00Z","timestamp":1228435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>14\u20103\u20103 Isoforms are shown to be upregulated or accumulated in the glial cells of autopsied patient brains affected with progressive multifocal leukoencephalopathy (PML), a demylinating disease caused by JC virus (JCV). The possible involvement of 14\u20103\u20103 in JCV tropism, however, has never been examined. To investigate a potential relationship between 14\u20103\u20103 isoforms and JCV <jats:italic>in vitro<\/jats:italic>, we examined the localization of six 14\u20103\u20103 isoforms in human neural progenitors and progenitor\u2010derived astrocytes (PDAs) in cells without JCV exposure. The 14\u20103\u20103 zeta isoform was initially localized in the progenitor cytoplasm. When differentiation of progenitors into PDAs was induced, the zeta isoform was translocated into the nucleus. However, upon JCV infection, progenitor cells exhibited an uncharacteristic 14\u20103\u20103 zeta nuclear presence in the few cells that became infected. JCV\u2010treated PDAs showed elevated levels of 14\u20103\u20103 zeta compared with noninfected PDAs. Treatment with TGF\u2010\u03b21, a known stimulant of JCV multiplication, increased the overall number of infected cells and the otherwise absent nuclear presence of 14\u20103\u20103 zeta in progenitors. These results suggest that the nuclear presence of 14\u20103\u20103 zeta may play a role in JCV infection, and that the isoform may in part determine JCV susceptibility in these cell types. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.20821","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T22:22:36Z","timestamp":1228515756000},"page":"971-977","source":"Crossref","is-referenced-by-count":13,"title":["Glial cell type\u2010specific subcellular localization of 14\u20103\u20103 zeta: An implication for JCV tropism"],"prefix":"10.1002","volume":"57","author":[{"given":"Shivani","family":"Lamba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerasamy","family":"Ravichandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene O.","family":"Major","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0300387"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1197"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550289509111006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280601009553"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1128\/jvi.70.11.7527-7534.1996","article-title":"Nonstructural proteins NS2 of minute virus of mice associate in vivo with 14\u20103\u20103 protein family members","volume":"70","author":"Brockhaus K","year":"1996","journal-title":"J Virol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21304"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205744"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550280009015824"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5858\/2004-128-282-EFIOTG","article-title":"Evidence for involvement of transforming growth factor \u03b21 signaling pathway in activation of JC virus in human immunodeficiency virus 1\u2010associated progressive multifocal leukoencephalopathy","volume":"128","author":"Enam S","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-32957-9_19"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0785-z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20933"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.40.23681"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-006-0022-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10523"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05447.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210742"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.19.10638-10644.2003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02658-06"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.2008\/000059-0"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0885-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3450297"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.09.012"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.20821","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.20821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T21:17:50Z","timestamp":1697491070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.20821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,5]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1002\/glia.20821"],"URL":"https:\/\/doi.org\/10.1002\/glia.20821","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,5]]}}}