{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:26:40Z","timestamp":1790508400095,"version":"4.1.0"},"reference-count":127,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T00:00:00Z","timestamp":1235088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cells from central nervous system with morphology similar to radial glia and properties intermediate between astrocytes and Schwann cells were called growth\u2010promoting glia or aldynoglia. These cells are present in adult brain olfactory bulb, hypothalamus, hypophysis, pineal gland and in the developing brain, and spinal cord (Cameron and Rakic (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib27\">1991<\/jats:ext-link>) Glia 4:124\u2013137; Gudi\u00f1o\u2010Cabrera and Nieto\u2010Sampedro (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib59\">2000<\/jats:ext-link>) 30:49\u201363). We report now that neurosphere cells, abundantly generated from E15 rat or E13 mouse corpus striatum, differentiate to aldynoglia\u2010like cells when plated onto an adhesive substrate, and cultured in the presence of olfactory ensheathing cell conditioned medium, supplemented with EGF and bFGF. The immunophenotype, mRNA expression (microarray and RT\u2010PCR analysis), neurite growth\u2010promoting and ensheathing properties of the cells derived from neurospheres were similar to those of aldynoglia. Neurosphere\u2010derived, aldynoglia\u2010like cells expressed, with respect to neurospheres, very increased levels of GFAP, high levels of nestin and vimentin, extracellular matrix proteins, and inhibitors of the catabolism of those extracellular matrix proteins. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.20858","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T23:06:14Z","timestamp":1235171174000},"page":"1393-1409","source":"Crossref","is-referenced-by-count":28,"title":["Neurosphere cell differentiation to aldynoglia promoted by olfactory ensheathing cell conditioned medium"],"prefix":"10.1002","volume":"57","author":[{"given":"Ernesto","family":"Doncel\u2010P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Caballero\u2010Chac\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Nieto\u2010Sampedro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490300103"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970901)49:5<608::AID-JNR11>3.0.CO;2-R"},{"key":"e_1_2_7_4_1","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff MD","year":"2004","journal-title":"Biophoton Int"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(200005)30:3<301::AID-GLIA9>3.0.CO;2-S"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(20000115)29:2<104::AID-GLIA2>3.0.CO;2-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012297132047"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEAB.0000036003.22350.3b"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.04.034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10160"},{"key":"e_1_2_7_11_1","first-page":"5251","article-title":"Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: Implications for mammary tumors","volume":"53","author":"Bacus SS","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_7_12_1","first-page":"133","volume-title":"Characterization of rat neural stem cells from embryonic striatum and mesencephalon during in vitro differentiation","author":"Baz\u00e1n E L\u2010TM","year":"1998"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1124"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4695(200103)46:4<265::AID-NEU1007>3.0.CO;2-B"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)90096-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1421"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(99)00099-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1136(200103)33:3<225::AID-GLIA1021>3.0.CO;2-Y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2833rev"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08852-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200604240-00013"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03321"},{"key":"e_1_2_7_23_1","first-page":"922","volume-title":"Molecular biology of the cell","author":"Bruce Alberts AJ","year":"2002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/3481"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80324-4"},{"issue":"4","key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/brain\/awl374","article-title":"Growth\u2010modulating molecules are associated with invading Schwann cells and not astrocytes in human traumatic spinal cord injury","volume":"130","author":"Buss A","year":"2007","journal-title":"Brain"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2000.00223.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440040204"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6657"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20117"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(95)80065-4"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(07)26003-3"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008087200"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21194"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02455-5"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00202-6"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90244-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1116"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2006.08.003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.55.091902.104338"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(99)00058-0"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440130206"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22719.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80561-9"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(01)00330-3"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7750"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10344"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.09.009"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E04-03-0171"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490320102"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.4.951"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-006-9127-2"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.129007"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:1:3:153"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-05990.1999"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NERE.0000018844.51009.40"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.05.080"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1433"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(19990915)40:4<458::AID-NEU4>3.0.CO;2-9"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(200003)30:1<49::AID-GLIA6>3.0.CO;2-M"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0046"},{"key":"e_1_2_7_62_1","first-page":"602","article-title":"Effects of annexins II, V on survival of neurons and astrocytes in vitro","volume":"25","author":"Han S","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020700117665"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00100-3"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.24.14523"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0945-053X(95)90006-3"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.2.564"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08573.x"},{"key":"e_1_2_7_69_1","first-page":"277","article-title":"The role of connective tissue growth factor in skeletal growth and development","volume":"12","author":"Kanaan RA","year":"2006","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS19980020"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.2.0234"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017423"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00815-0"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7599"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200216060-00001"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb09692.x"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00727.2003"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(02)00058-4"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20607"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100111"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1353"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.12.001"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2002.1130"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7669"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740648"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407893101"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/378386a0"},{"key":"e_1_2_7_88_1","first-page":"7","article-title":"Differentiation of epidermal growth factor\u2010responsive neural precursor cells within neurospheres","volume":"39","author":"Mokr\u00fd J","year":"1996","journal-title":"Acta Medica"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91059-P"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199902)45:2<207::AID-ANA11>3.0.CO;2-K"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)36026-6"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026056921037"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.08.017"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088100"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<755::AID-JNR12>3.0.CO;2-0"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)28024-2"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90134-N"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00971.x"},{"key":"e_1_2_7_99_1","volume-title":"ImageJ","author":"Rasband WS","year":"1997"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1553558"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21040"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10374"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00135.x"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20479"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-9335(98)80006-X"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20846"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0402-e65"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.8.2955-2964.2006"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2007.4"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(98)00134-7"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00130.2007"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2004.825627"},{"key":"e_1_2_7_113_1","first-page":"725","article-title":"Integrin function and regulation in development","volume":"44","author":"Tarone G","year":"2000","journal-title":"Int J Dev Biol"},{"key":"e_1_2_7_114_1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1523\/JNEUROSCI.18-05-01795.1998","article-title":"Functional cooperation of beta1\u2010integrins and members of the Ig superfamily in neurite outgrowth induction","volume":"18","author":"Treubert U","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.731"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.137.1.211"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200108080-00005"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00895.2003"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20195"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-004-2097-5"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(02)00509-6"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.11045"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20120"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.07.005"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1034"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80454-7"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00330-7"},{"key":"e_1_2_7_128_1","first-page":"1606","article-title":"Sorbitol causes preferential selection of Muller glial precursors from late retinal progenitor cells in vitro","volume":"12","author":"Zahir T","year":"2006","journal-title":"Mol Vis"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.20858","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.20858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T21:10:35Z","timestamp":1699909835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.20858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,20]]},"references-count":127,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1002\/glia.20858"],"URL":"https:\/\/doi.org\/10.1002\/glia.20858","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,20]]}}}