{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:07:34Z","timestamp":1792735654986,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T00:00:00Z","timestamp":1245283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Astrocytes are well known modulators of normal developmental retinal vascularization. However, relatively little is known about the role of glial cells during pathological retinal neovascularization (NV), a leading contributor to vision loss in industrialized nations. We demonstrate that the loss of astrocytes and microglia directly correlates with the development of pathological NV in a mouse model of oxygen\u2010induced retinopathy (OIR). These two distinct glial cell populations were found to have cooperative survival effects\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . The intravitreal injection of myeloid progenitor cells, astrocytes, or astrocyte\u2010conditioned media rescued endogenous astrocytes from degeneration that normally occurs within the hypoxic, vaso\u2010obliterated retina following return to normoxia. Protection of the retinal astrocytes and microglia was directly correlated with accelerated revascularization of the normal retinal plexuses and reduction of pathological intravitreal NV normally associated with OIR. Using astrocyte\u2010conditioned media, several factors were identified that may contribute to the observed astrocytic protection and subsequent normalization of the retinal vasculature, including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Injection of VEGF or bFGF at specific doses rescued the retinas from developing OIR\u2010associated pathology, an effect that was also preceded by protection of endogenous glia from hypoxia\u2010induced degeneration. Together, these data suggest that vascular\u2010associated glia are also required for normalized revascularization of the hypoxic retina. Methods developed to target and protect glial cells may provide a novel strategy by which normalized revascularization can be promoted and the consequences of abnormal NV in retinal vascular diseases can be prevented. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/glia.20900","type":"journal-article","created":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T13:42:37Z","timestamp":1245332557000},"page":"43-54","source":"Crossref","is-referenced-by-count":114,"title":["Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen\u2010induced retinopathy"],"prefix":"10.1002","volume":"58","author":[{"given":"Michael 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