{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:15Z","timestamp":1786977795710,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,8,24]],"date-time":"2009-08-24T00:00:00Z","timestamp":1251072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In peripheral nerve injury, Schwann cells undergo profound phenotypic modulation, adopting a migratory phenotype and remodeling the extracellular matrix so that it is permissive for axonal regrowth. Erythropoietin (Epo) and its receptor (EpoR) are expressed by Schwann cells after nerve injury, regulating inflammatory cytokine expression and minimizing the duration of neuropathic pain. The mechanism of Epo activity in the injured peripheral nerve remains incompletely understood. Herein, we demonstrate that Epo promotes Schwann cell migration\n                    <jats:italic>in vitro<\/jats:italic>\n                    on fibronectin (FN)\u2010coated surfaces. Epo also rapidly recruits \u03b21 integrin subunit to the Schwann cell surface by a JAK\u20102\u2010dependent pathway. Although \u03b21 integrin subunit\u2010containing integrins were not principally responsible for Schwann cell adhesion or migration on FN under basal conditions, \u03b21 gene\u2010silencing blocked the ability of Epo to promote cell migration. Epo also induced Schwann cell FN expression\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . The FN was organized into insoluble fibrils by Epo\u2010treated Schwann cells\n                    <jats:italic>in vitro<\/jats:italic>\n                    and into an extensive matrix surrounding Schwann cells\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Our results support a model in which Epo promotes Schwann cell migration and assembly of the provisional extracellular matrix in the injured peripheral nerve by its effects on integrin recruitment to the cell surface and local FN production. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/glia.20931","type":"journal-article","created":{"date-parts":[[2009,8,24]],"date-time":"2009-08-24T14:14:24Z","timestamp":1251123264000},"page":"399-409","source":"Crossref","is-referenced-by-count":29,"title":["Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting \u03b21 integrin to the cell surface"],"prefix":"10.1002","volume":"58","author":[{"given":"Gen","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Gaultier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Mantuano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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