{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:56:55Z","timestamp":1791633415750,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1707,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1002\/glia.21116","type":"journal-article","created":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T20:45:22Z","timestamp":1293655522000},"page":"463-471","source":"Crossref","is-referenced-by-count":114,"title":["Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells"],"prefix":"10.1002","volume":"59","author":[{"given":"Doreen","family":"Braun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja U.","family":"Br\u00e4uer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Sapin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc O.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"K\u00f6hrle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva K.","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,29]]},"reference":[{"key":"10.1002\/glia.21116-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1242\/dev.120.5.1097","article-title":"A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development","volume":"120","author":"Barres","year":"1994","journal-title":"Development"},{"key":"10.1002\/glia.21116-BIB2|cit2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/mvre.2001.2318","article-title":"*NO and oxyradical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier","volume":"62","author":"Blasig","year":"2001","journal-title":"Microvasc Res"},{"key":"10.1002\/glia.21116-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1471-4159.1993.tb03302.x","article-title":"Triiodothyronine is a high-affinity inhibitor of amino acid transport system L1 in cultured astrocytes","volume":"60","author":"Blondeau","year":"1993","journal-title":"J Neurochem"},{"key":"10.1002\/glia.21116-BIB4|cit4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1515\/REVNEURO.2010.21.3.173","article-title":"Thyroid hormone transporters in the brain","volume":"21","author":"Braun","year":"2010","journal-title":"Rev Neurosci"},{"key":"10.1002\/glia.21116-BIB5|cit5","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/j.1471-4159.2007.04654.x","article-title":"Alanine metabolism, transport, and cycling in the brain","volume":"102","author":"Br\u00f6er","year":"2007","journal-title":"J Neurochem"},{"key":"10.1002\/glia.21116-BIB6|cit6","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1046\/j.1471-4159.1995.65062549.x","article-title":"Characterization of the thyroid hormone transport system of cerebrocortical rat neurons in primary culture","volume":"65","author":"Chantoux","year":"1995","journal-title":"J Neurochem"},{"key":"10.1002\/glia.21116-BIB7|cit7","unstructured":"Christensen HN 1975 Current topics in membranes and transport 6 New York Academic Press"},{"key":"10.1002\/glia.21116-BIB8|cit8","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1172\/JCI109749","article-title":"Rapid thyroxine to 3,5,3\u2032-triiodothyronine conversion and nuclear 3,5,3\u2032-triiodothyronine binding in rat cerebral cortex and cerebellum","volume":"65","author":"Crantz","year":"1980","journal-title":"J Clin Invest"},{"key":"10.1002\/glia.21116-BIB9|cit9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-8993(91)90194-Z","article-title":"Transport of iodothyronines from bloodstream to brain: Contributions by blood:brain and choroid plexus:cerebrospinal fluid barriers","volume":"554","author":"Dratman","year":"1991","journal-title":"Brain Res"},{"key":"10.1002\/glia.21116-BIB10|cit10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1086\/380999","article-title":"A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene","volume":"74","author":"Dumitrescu","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1002\/glia.21116-BIB11|cit11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/glia.1058","article-title":"An immortalized jimpy oligodendrocyte cell line: Defects in cell cycle and cAMP pathway","volume":"34","author":"Feutz","year":"2001","journal-title":"Glia"},{"key":"10.1002\/glia.21116-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/j.1471-4159.1989.tb08538.x","article-title":"Carrier-mediated transport of thyroid hormones into rat glial cells in primary culture","volume":"53","author":"Francon","year":"1989","journal-title":"J Neurochem"},{"key":"10.1002\/glia.21116-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1172\/JCI41977","article-title":"Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells","volume":"120","author":"Freitas","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1002\/glia.21116-BIB14|cit14","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1210\/en.142.10.4339","article-title":"Thyroid hormone transport by the heterodimeric human system L amino acid transporter","volume":"142","author":"Friesema","year":"2001","journal-title":"Endocrinology"},{"key":"10.1002\/glia.21116-BIB15|cit15","doi-asserted-by":"crossref","first-page":"40128","DOI":"10.1074\/jbc.M300909200","article-title":"Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter","volume":"278","author":"Friesema","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.21116-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S0140-6736(04)17226-7","article-title":"Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation","volume":"364","author":"Friesema","year":"2004","journal-title":"Lancet"},{"key":"10.1002\/glia.21116-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1210\/me.2007-0112","article-title":"Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10","volume":"22","author":"Friesema","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1002\/glia.21116-BIB18|cit18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/glia.10122","article-title":"Trafficking of PLP\/DM20 and cAMP signaling in immortalized jimpy oligodendrocytes","volume":"40","author":"Ghandour","year":"2002","journal-title":"Glia"},{"key":"10.1002\/glia.21116-BIB19|cit19","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1523\/JNEUROSCI.19-09-03430.1999","article-title":"Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems","volume":"19","author":"Guadano-Ferraz","year":"1999","journal-title":"J Neurosci"},{"key":"10.1002\/glia.21116-BIB20|cit20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.beem.2007.03.004","article-title":"Cellular entry of thyroid hormones by organic anion transporting polypeptides","volume":"21","author":"Hagenbuch","year":"2007","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1002\/glia.21116-BIB21|cit21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1210\/er.22.4.451","article-title":"Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability","volume":"22","author":"Hennemann","year":"2001","journal-title":"Endocr Rev"},{"key":"10.1002\/glia.21116-BIB22|cit22","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1210\/en.2004-1179","article-title":"The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations","volume":"146","author":"Heuer","year":"2005","journal-title":"Endocrinology"},{"key":"10.1002\/glia.21116-BIB23|cit23","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1177\/08830738050200101601","article-title":"X-linked MCT8 gene mutations: Characterization of the pediatric neurologic phenotype","volume":"20","author":"Holden","year":"2005","journal-title":"J Child Neurol"},{"key":"10.1002\/glia.21116-BIB24|cit24","doi-asserted-by":"crossref","first-page":"28054","DOI":"10.1074\/jbc.M110.129577","article-title":"Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8","volume":"285","author":"Kinne","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.21116-BIB25|cit25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1677\/JME-09-0043","article-title":"Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent","volume":"43","author":"Kinne","year":"2009","journal-title":"J Mol Endocrinol"},{"key":"10.1002\/glia.21116-BIB26|cit26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.beem.2007.04.001","article-title":"Thyroid hormone transporters in health and disease: Advances in thyroid hormone deiodination","volume":"21","author":"K\u00f6hrle","year":"2007","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1002\/glia.21116-BIB27|cit27","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1089\/thy.2005.15.883","article-title":"Role of thyroid hormone deiodination in the hypothalamus","volume":"15","author":"Lechan","year":"2005","journal-title":"Thyroid"},{"key":"10.1002\/glia.21116-BIB28|cit28","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.7291997","article-title":"Cerebral cortex responds rapidly to thyroid hormones","volume":"214","author":"Leonard","year":"1981","journal-title":"Science"},{"key":"10.1002\/glia.21116-BIB29|cit29","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1073\/pnas.062413299","article-title":"Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism","volume":"99","author":"Morte","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/glia.21116-BIB30|cit30","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00431-007-0589-6","article-title":"Clinical phenotype and endocrinological investigations in a patient with a mutation in the MCT8 thyroid hormone transporter","volume":"167","author":"Namba","year":"2008","journal-title":"Eur J Pediatr"},{"key":"10.1002\/glia.21116-BIB31|cit31","doi-asserted-by":"crossref","first-page":"19738","DOI":"10.1074\/jbc.274.28.19738","article-title":"Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids","volume":"274","author":"Pineda","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.21116-BIB32|cit32","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1677\/joe.0.163R005","article-title":"Thyroid hormone transport by 4F2hc-IU12 heterodimers expressed in Xenopus oocytes","volume":"163","author":"Ritchie","year":"1999","journal-title":"J Endocrinol"},{"key":"10.1002\/glia.21116-BIB33|cit33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuroscience.2008.06.015","article-title":"Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation","volume":"155","author":"Roberts","year":"2008a","journal-title":"Neuroscience"},{"key":"10.1002\/glia.21116-BIB34|cit34","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1210\/en.2008-0378","article-title":"Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier","volume":"149","author":"Roberts","year":"2008b","journal-title":"Endocrinology"},{"key":"10.1002\/glia.21116-BIB35|cit35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/bj20021853","article-title":"Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues","volume":"370","author":"Schomburg","year":"2003","journal-title":"Biochem J"},{"key":"10.1002\/glia.21116-BIB36|cit36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1086\/431313","article-title":"Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene","volume":"77","author":"Schwartz","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1002\/glia.21116-BIB37|cit37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2008.04.007","article-title":"Think globally: Act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas","volume":"289","author":"Schweizer","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"10.1002\/glia.21116-BIB38|cit38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbrc.2005.09.102","article-title":"Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice","volume":"337","author":"Streckfuss","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/glia.21116-BIB39|cit39","doi-asserted-by":"crossref","first-page":"43489","DOI":"10.1074\/jbc.M306933200","article-title":"Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: High affinity transporter for thyroxine","volume":"278","author":"Sugiyama","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.21116-BIB40|cit40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1172\/JCI28253","article-title":"Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8","volume":"117","author":"Trajkovic","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1002\/glia.21116-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1172\/JCI111138","article-title":"Sources and quantity of 3,5,3\u2032-triiodothyronine in several tissues of the rat","volume":"72","author":"van Doorn","year":"1983","journal-title":"J Clin Invest"},{"key":"10.1002\/glia.21116-BIB42|cit42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.beem.2007.03.008","article-title":"Thyroid hormone transport by monocarboxylate transporters","volume":"21","author":"Visser","year":"2007","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1002\/glia.21116-BIB43|cit43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/humu.20808","article-title":"Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations","volume":"30","author":"Visser","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1002\/glia.21116-BIB44|cit44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0070-2153(07)80004-4","article-title":"Organic anion-transporting polypeptides at the blood-brain and blood-cerebrospinal fluid barriers","volume":"80","author":"Westholm","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"10.1002\/glia.21116-BIB45|cit45","doi-asserted-by":"crossref","first-page":"9439","DOI":"10.1523\/JNEUROSCI.6055-08.2009","article-title":"Neuronal 3\u2032,3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome","volume":"29","author":"Wirth","year":"2009","journal-title":"J Neurosci"},{"key":"10.1002\/glia.21116-BIB46|cit46","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1210\/en.2004-1392","article-title":"Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse","volume":"146","author":"Zavacki","year":"2005","journal-title":"Endocrinology"},{"key":"10.1002\/glia.21116-BIB47|cit47","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2826.2004.01243.x","article-title":"Timing of thyroid hormone action in the developing brain: Clinical observations and experimental findings","volume":"16","author":"Zoeller","year":"2004","journal-title":"J Neuroendocrinol"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.21116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/glia.21116\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T13:11:28Z","timestamp":1637068288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.21116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,29]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"URL":"https:\/\/doi.org\/10.1002\/glia.21116","relation":{},"ISSN":["0894-1491"],"issn-type":[{"value":"0894-1491","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12,29]]}}}