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By examining the primary auditory (A1) and visual (V1) cortices in two inbred strains of mice undergoing either age\u2010related loss of audition (C57BL\/6J) or vision (CBA\/CaJ), we were able to describe cellular and subcellular changes that were associated with normal aging (occurring in A1 and V1 of both strains) or specifically with age\u2010related sensory loss (only in A1 of C57BL\/6J or V1 of CBA\/CaJ), using immunocytochemical electron microscopy and light microscopy. While the changes were subtle in neurons, glial cells and especially microglia were transformed in aged animals. Microglia became more numerous and irregularly distributed, displayed more variable cell body and process morphologies, occupied smaller territories, and accumulated phagocytic inclusions that often displayed ultrastructural features of synaptic elements. Additionally, evidence of myelination defects were observed, and aged oligodendrocytes became more numerous and were more often encountered in contiguous pairs. Most of these effects were profoundly exacerbated by age\u2010related sensory loss. Together, our results suggest that the age\u2010related alteration of glial cells in sensory cortical areas can be accelerated by activity\u2010driven central mechanisms that result from an age\u2010related loss of peripheral sensitivity. In light of our observations, these age\u2010related changes in sensory function should be considered when investigating cellular, cortical, and behavioral functions throughout the lifespan in these commonly used C57BL\/6J and CBA\/CaJ mouse models. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/glia.22287","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T11:22:55Z","timestamp":1325848975000},"page":"541-558","source":"Crossref","is-referenced-by-count":299,"title":["Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices"],"prefix":"10.1002","volume":"60","author":[{"given":"Marie\u2010\u00c8ve","family":"Tremblay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha L.","family":"Zettel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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