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Using GFAP\u2010I\u03baB\u03b1\u2010dn mice in which NF\u2010 \u03baB transcriptional activation is inhibited in SCs, we found no discernable differences in the quantity or structure of myelinated axons in adult facial nerves. Following crush injury, axonal regeneration was impaired at 31 days and significantly enhanced at 65 days in transgenic animals. Compact remyelination and Remak bundle organization were significantly compromised at 31 days and restored by 65 days post injury. Together, these data indicate that inhibition of NF\u2010\u03baB activation in SCs transiently delays axonal regeneration and compact remyelination. Manipulating the temporal activation of nuclear factor\u2010\u03baB in Schwann cells may offer new therapeutic avenues for PNS and CNS regeneration. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/glia.22297","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T19:50:30Z","timestamp":1327434630000},"page":"639-650","source":"Crossref","is-referenced-by-count":26,"title":["Nuclear factor\u2010\u03baB activation in schwann cells regulates regeneration and remyelination"],"prefix":"10.1002","volume":"60","author":[{"given":"Paul D.","family":"Morton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua T.","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel Y.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel 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