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In epilepsy\u2010associated pathologies, the presence of astrogliosis has stimulated extensive research focused on the role of reactive astrocytes in the pathophysiological processes that underlie the development of epilepsy. In brain tissue from patients with epilepsy, astrocytes undergo significant changes in their physiological properties, including the activation of inflammatory pathways. Accumulating experimental evidence suggests that proinflammatory molecules can alter glio\u2010neuronal communications contributing to the generation of seizures and seizure\u2010related neuronal damage. In particular, both<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>data point to the role of astrocytes as both major source and target of epileptogenic inflammatory signaling. In this context, understanding the astroglial inflammatory response occurring in epileptic brain tissue may provide new strategies for targeting astrocyte\u2010mediated epileptogenesis. This article reviews current evidence regarding the role of astrocytes in the regulation of the innate immune responses in epilepsy. Both clinical observations in drug\u2010resistant human epilepsies and experimental findings in clinically relevant models will be discussed and elaborated, highlighting specific inflammatory pathways (such as interleukin\u20101\u03b2\/toll\u2010like receptor 4) that could be potential targets for antiepileptic, disease\u2010modifying therapeutic strategies. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/glia.22312","type":"journal-article","created":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T19:34:32Z","timestamp":1329161672000},"page":"1258-1268","source":"Crossref","is-referenced-by-count":186,"title":["Astrocyte immune responses in 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