{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:41:30Z","timestamp":1791855690850,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schwann cell (SC) implantation after spinal cord injury (SCI) promotes axonal regeneration, remyelination repair, and functional recovery. Reparative efficacy, however, may be limited because of the inability of SCs to migrate outward from the lesion\u2010implant site. Altering SC cell surface properties by overexpressing polysialic acid (PSA) has been shown to promote SC migration. In this study, a SCI contusion model was used to evaluate the migration, supraspinal axon growth support, and functional recovery associated with polysialyltransferase (PST)\u2010overexpressing SCs [PST\u2010green fluorescent protein (GFP) SCs] or controls (GFP SCs). Compared with GFP SCs, which remained confined to the injection site at the injury center, PST\u2010GFP SCs migrated across the lesion:host cord interface for distances of up to 4.4 mm within adjacent host tissue. In addition, with PST\u2010GFP SCs, there was extensive serotonergic and corticospinal axon in\u2010growth within the implants that was limited in the GFP SC controls. The enhanced migration of PST\u2010GFP SCs was accompanied by significant growth of these axons caudal to lesion. Animals receiving PST\u2010GFP SCs exhibited improved functional outcome, both in the open\u2010field and on the gridwalk test, beyond the modest improvements provided by GFP SC controls. This study for the first time demonstrates that a lack of migration by SCs may hinder their reparative benefits and that cell surface overexpression of PSA enhances the ability of implanted SCs to associate with and support the growth of corticospinal axons. These results provide further promise that PSA\u2010modified SCs will be a potent reparative approach for SCI. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/glia.22330","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T11:48:13Z","timestamp":1333021693000},"page":"979-992","source":"Crossref","is-referenced-by-count":79,"title":["Extensive cell migration, axon regeneration, and improved function with polysialic acid\u2010modified Schwann cells after spinal cord injury"],"prefix":"10.1002","volume":"60","author":[{"given":"Mousumi","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis 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