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Because we found a4 mRNA highly expressed in C6Bu1 glioma cell line, we measured it in 205 glioma biopsies and 11 brain biopsies from epileptic patients. a4 was absent in epileptic brain biopsies, but was expressed by 34% (11\/32) of grade III oligodendrogliomas, independently of the chromosome 1p19q codeletion. a4 expression in grade III oligodendrogliomas and oligoastrocytomas without the 1p19q codeletion tended to be associated with a shorter overall survival of patients. We also observed a4 expression in biopsies of pilocytic astrocytomas (68%; 19\/28) and gangliogliomas (37%; 6\/16). In pilocytic astrocytomas a4 expression was associated with a tandem duplication of the 7q34 chromosome region, distant 0.5 Mb to the <jats:italic>ATP6V0A4<\/jats:italic> gene locus. In conclusion, a4 expression identifies subtypes of oligodendrogliomas, pilocytic astrocytomas and gangliogliomas and may contribute to refine characterization of these tumors. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/glia.22332","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T11:49:09Z","timestamp":1333021749000},"page":"1004-1012","source":"Crossref","is-referenced-by-count":21,"title":["The renal v\u2010ATPase a4 subunit is expressed in specific subtypes of human 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