{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:19:50Z","timestamp":1790705990621,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pax\u20103 is a paired domain transcription factor that plays many roles during vertebrate development. In the Schwann cell lineage, Pax\u20103 is expressed at an early stage in Schwann cells precursors of the embryonic nerve, is maintained in the nonmyelinating cells of the adult nerve, and is upregulated in Schwann cells after peripheral nerve injury. Consistent with this expression pattern, Pax\u20103 has previously been shown to play a role in repressing the expression of the myelin basic protein gene in Schwann cells. We have studied the role of Pax\u20103 in Schwann cells and have found that it controls not only the regulation of cell differentiation but also the survival and proliferation of Schwann cells. Pax\u20103 expression blocks both the induction of Oct\u20106 and Krox\u201020 (K20) by cyclic AMP and completely inhibits the ability of K20, the physiological regulator of myelination in the peripheral nervous system, to induce myelin gene expression in Schwann cells. In contrast to other inhibitors of myelination, we find that Pax\u20103 represses myelin gene expression in a c\u2010Jun\u2010independent manner. In addition to this, we find that Pax\u20103 expression alone is sufficient to inhibit the induction of apoptosis by TGF\u03b21 in Schwann cells. Expression of Pax\u20103 is also sufficient to induce the proliferation of Schwann cells in the absence of added growth factors and to reverse K20\u2010induced exit from the cell cycle. These findings indicate new roles for the Pax\u20103 transcription factor in controlling the differentiation and proliferation of Schwann cells during development and after peripheral nerve injury. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/glia.22346","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T23:18:52Z","timestamp":1335309532000},"page":"1269-1278","source":"Crossref","is-referenced-by-count":58,"title":["Regulation of Schwann cell differentiation and proliferation by the Pax\u20103 transcription factor"],"prefix":"10.1002","volume":"60","author":[{"given":"Robin D. 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