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Here we used cultured primary Schwann cells to demonstrate that active Rac1 GTPase (Rac) functions as a negative regulator of Schwann cell differentiation by upregulating c\u2010jun and downregulating Krox20 through the MKK7\u2010JNK pathway, but not through the Raf\u2010ERK pathway. The activation of MKK7 and induction of c\u2010jun in sciatic nerves after axotomy was blocked by Rac inhibition. Microarray experiments revealed that the expression of regeneration\u2010associated genes, such as <jats:italic>glial cell line\u2010derived neurotrophic factor<\/jats:italic> and <jats:italic>p75 neurotrophin receptor<\/jats:italic>, after nerve injury was dependent on Rac but not on ERK. Finally, the inhibition of ErbB2 signaling prevented MKK7 activation, c\u2010jun induction, and Rac\u2010dependent gene expression in sciatic nerve explant cultures. Taken together, our results indicate that the neuregulin\u2010Rac\u2010MKK7\u2010JNK\/c\u2010jun pathway regulates Schwann cell dedifferentiation following nerve injury.<\/jats:p>","DOI":"10.1002\/glia.22482","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T20:35:07Z","timestamp":1363379707000},"page":"892-904","source":"Crossref","is-referenced-by-count":45,"title":["The Neuregulin\u2010Rac\u2010MKK7 pathway regulates antagonistic c\u2010jun\/Krox20 expression in Schwann cell dedifferentiation"],"prefix":"10.1002","volume":"61","author":[{"given":"Yoon Kyung","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Physiology and Mitochondria Hub Regulation Center (MHRC) College of Medicine Dong\u2010A University Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Mitochondria Hub Regulation Center 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