{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:51:47Z","timestamp":1790970707514,"version":"4.1.0"},"reference-count":159,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T00:00:00Z","timestamp":1366156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Neuron\u2013glia interactions play a key role in maintaining and regulating the central nervous system. Glial cells are implicated in the function of dopamine neurons and regulate their survival and resistance to injury. Parkinson's disease is characterized by the loss of dopamine neurons in the substantia nigra pars compacta, decreased striatal dopamine levels and consequent onset of extrapyramidal motor dysfunction. Parkinson's disease is a common chronic, neurodegenerative disorder with no effective protective treatment. In the 6\u2010OHDA mouse model of Parkinson's disease, doxycycline administered at a dose that both induces\/represses conditional transgene expression in the tetracycline system, mitigates the loss of dopaminergic neurons in the substantia nigra compacta and nerve terminals in the striatum. This protective effect was associated with: (1) a reduction of microglia in normal mice as a result of doxycycline administration <jats:italic>per se<\/jats:italic>; (2) a decrease in the astrocyte and microglia response to the neurotoxin 6\u2010OHDA in the globus pallidus and substantia nigra compacta, and (3) the astrocyte reaction in the striatum. Our results suggest that doxycycline blocks 6\u2010OHDA neurotoxicity <jats:italic>in vivo<\/jats:italic> by inhibiting microglial and astrocyte expression. This action of doxycycline in nigrostriatal dopaminergic neuron protection is consistent with a role of glial cells in Parkinson's disease neurodegeneration. The neuroprotective effect of doxycycline may be useful in preventing or slowing the progression of Parkinson's disease and other neurodegenerative diseases linked to glia function.<\/jats:p>","DOI":"10.1002\/glia.22496","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T14:03:26Z","timestamp":1366207406000},"page":"1084-1100","source":"Crossref","is-referenced-by-count":105,"title":["Doxycycline restrains glia and confers neuroprotection in a 6\u2010OHDA Parkinson model"],"prefix":"10.1002","volume":"61","author":[{"given":"Marcio","family":"Lazzarini","sequence":"first","affiliation":[{"name":"Department of Morphology, Physiology and Pathology School of Odontology of Ribeir\u00e3o Preto (FORP) University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto SP Brazil"},{"name":"Department of Neurology, Medical School FMRP University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology of Neuronal Signals Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"},{"name":"Cluster of Excellence \u201cCenter Nanoscale Microscopy and Molecular Physiology of the Brain\u201d (CNMPB) G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u0161o","family":"Mitkovski","sequence":"additional","affiliation":[{"name":"Cluster of Excellence \u201cCenter Nanoscale Microscopy and Molecular Physiology of the Brain\u201d (CNMPB) G\u00f6ttingen Germany"},{"name":"Light Microscopy Facility Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Raisman","family":"Vozari","sequence":"additional","affiliation":[{"name":"INSERM UMR 975 \u2013 CNRS UMR 7225 Universit\u00e9 Pierre et Marie Curie CRICM6 ICM Th\u00e9rapeutique Exp\u00e9rimentale de la Neurod\u00e9g\u00e9n\u00e9rescence Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"St\u00fchmer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology of Neuronal Signals Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"},{"name":"Cluster of Excellence \u201cCenter Nanoscale Microscopy and Molecular Physiology of the Brain\u201d (CNMPB) G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Del","family":"Bel","sequence":"additional","affiliation":[{"name":"Department of Morphology, Physiology and Pathology School of Odontology of Ribeir\u00e3o Preto (FORP) University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto SP Brazil"},{"name":"Department of Neurology, Medical School FMRP University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199802000-00033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90857-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.01.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.14014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00605-4"},{"key":"e_1_2_6_7_1","first-page":"17","article-title":"The penetration of doxycycline into CSF","author":"Andersson H","year":"1976","journal-title":"Scand J Infect Dis"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.795"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10242"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130205"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440070117"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7403847"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.8.6.713"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280290101102"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02454138"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/845618"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.07.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(98)70367-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01189-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000121571.78696.dc"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026043387854"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf133"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703406"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.10.013"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70041584.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00799.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00294-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/77528"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-009-9078-1"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301377"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.7.1411"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02736854"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/neur.1996.0020"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90175-F"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1262"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.05.016"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2003.03014.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03372.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.10.001"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7935"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-010-9334-x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251341998"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03799.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301582"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.20.9302"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01626.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.03.005"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-006-9015-5"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.08.002"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.016"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411910020030201"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120010501"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.01.088"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7792603"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.10.037"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1997"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02681-6"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02459-2"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NERE.0000014822.69384.0f"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2008.09.001"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-15"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.01.027"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01471-1"},{"key":"e_1_2_6_64_1","first-page":"9","article-title":"Glial cell participation in the degeneration of dopaminergic neurons in Parkinson's disease","volume":"80","author":"Hirsch EC","year":"1999","journal-title":"Adv Neurol"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440717"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69010076.x"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03439.x"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/1055-8330(95)90015-2"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600025"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.06.010"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.090061"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00050.2004"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0929"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.09.040"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0132"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-16-06309.2000"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10933"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30039-6"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2010.08.003"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(93)90481-8"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199910)46:4<598::AID-ANA7>3.0.CO;2-F"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00571-4"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.12.012"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02780.x"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2007.00035.x"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.63.7_suppl_2.S23"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7152"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/70978"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.035048"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.043166"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1988"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.02.002"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1973145852"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62010045.x"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80533-4"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.05.019"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120604"},{"issue":"2","key":"e_1_2_6_98_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00002093-199803001-00001","article-title":"Glial cell reactions in neurodegenerative diseases: Pathophysiology and therapeutic interventions","volume":"12","author":"McGeer PL","year":"1998","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:25:3:245"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.308.5723.778"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.41"},{"key":"e_1_2_6_102_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0306-4522(99)00455-8","article-title":"The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease","volume":"95","author":"Mirza B","year":"2000","journal-title":"Neuroscience"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00159-7"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-05-01659.2003"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00237-6"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00040"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.01.034"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(96)00168-2"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2011.15.2.115"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00194-7"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00096"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.123757"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.10.008"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2010.07.001"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199709000-00017"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/6165"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207450108986528"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20051"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb09802.x"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21878"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200106000-00051"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-1-6"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90605-X"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(96)00040-8"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20233"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.4065\/74.7.727"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10614"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.09.005"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.125989"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.04.047"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-35109-2_3"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-35109-2_14"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5275-03.2004"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858405275175"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90632-4"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.08.013"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.041335"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0944-0"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043453162"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7527"},{"key":"e_1_2_6_142_1","first-page":"23","article-title":"Inducible transgene expression in mouse stem cells","volume":"105","author":"Ting DT","year":"2005","journal-title":"Methods Mol Med"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006058801600404"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.01.011"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200206120-00018"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200108000-00009"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000089090.05757.34"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600988"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20484"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.12.005"},{"key":"e_1_2_6_151_1","first-page":"1346","article-title":"Protective effects of doxycycline upon dopaminergic neuron in LPS\u2010induced rat model of Parkinson's disease","volume":"89","author":"Wang PQ","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1832501100"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-05-01763.2002"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10709"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.2.347"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00937-8"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15769"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13496"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1661-07.2007"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/417074a"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.22496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.22496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:46:25Z","timestamp":1696376785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.22496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,17]]},"references-count":159,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/glia.22496"],"URL":"https:\/\/doi.org\/10.1002\/glia.22496","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,17]]}}}