{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:32:54Z","timestamp":1791419574236,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>\n                    The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble amyloid \u03b2 (A\u03b2) is an initiator of a cascade of events eventually leading to neurodegeneration. Recently, we reported that A\u03b2 deranged Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis specifically in hippocampal astrocytes by targeting key elements of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling, such as mGluR5 and IP\n                    <jats:sub>3<\/jats:sub>\n                    R1. In the present study, we dissect a cascade of signaling events by which A\u03b2 deregulates glial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    : (i) 100 nM A\u03b2 leads to an increase in cytosolic calcium after 4\u20136 h of treatment; (ii) mGluR5 is increased after 24 h of treatment; (iii) this increase is blocked by inhibitors of calcineurin (CaN) and NF\u2010kB. Furthermore, we show that A\u03b2 treatment of glial cells leads to de\u2010phosphorylation of Bcl10 and an increased CaN\u2010Bcl10 interaction. Last, mGluR5 staining is augmented in hippocampal astrocytes of AD patients in proximity of A\u03b2 plaques and co\u2010localizes with nuclear accumulation of the p65 NF\u2010kB subunit and increased staining of CaNA\u03b1. Taken together our data suggest that nanomolar [A\u03b2] deregulates Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis via CaN and its downstream target NF\u2010kB, possibly via the cross\u2010talk of Bcl10 in hippocampal astrocytes.\n                  <\/jats:p>","DOI":"10.1002\/glia.22502","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T04:36:37Z","timestamp":1366864597000},"page":"1134-1145","source":"Crossref","is-referenced-by-count":164,"title":["Amyloid beta deregulates astroglial mGluR5\u2010mediated calcium signaling via calcineurin and Nf\u2010kB"],"prefix":"10.1002","volume":"61","author":[{"given":"Dmitry","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro,\u201d Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of (Neuro)Pathology Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Ronco","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro,\u201d Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra A.","family":"Grolla","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro,\u201d Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Canonico","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro,\u201d Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[{"name":"Department of (Neuro)Pathology Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"},{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands"},{"name":"Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando A.","family":"Genazzani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro,\u201d Novara 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