{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:18:47Z","timestamp":1791296327039,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>\n                    Spinal muscular atrophy (SMA) is a genetic disorder caused by the deletion of the survival motor neuron 1 (\n                    <jats:italic>SMN1<\/jats:italic>\n                    ) gene that leads to loss of motor neurons in the spinal cord. Although motor neurons are selectively lost during SMA pathology, selective replacement of\n                    <jats:italic>SMN<\/jats:italic>\n                    in motor neurons does not lead to full rescue in mouse models. Due to the ubiquitous expression of SMN, it is likely that other cell types besides motor neurons are affected by its disruption and therefore may contribute to disease pathology. Here we show that astrocytes in SMA\u03947 mouse spinal cord and from SMA\u2010induced pluripotent stem cells exhibit morphological and cellular changes indicative of activation before overt motor neuron loss. Furthermore, our\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies show mis\u2010regulation of basal calcium and decreased response to adenosine triphosphate stimulation indicating abnormal astrocyte function. Together, for the first time, these data show early disruptions in astrocytes that may contribute to SMA disease pathology.\n                  <\/jats:p>","DOI":"10.1002\/glia.22522","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T03:49:39Z","timestamp":1373428179000},"page":"1418-1428","source":"Crossref","is-referenced-by-count":156,"title":["Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production"],"prefix":"10.1002","volume":"61","author":[{"given":"Jered V.","family":"McGivern","sequence":"first","affiliation":[{"name":"Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa N.","family":"Patitucci","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Nord","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Elizabeth A.","family":"Barabas","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Stucky","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison D.","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin Milwaukee 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