{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:44:21Z","timestamp":1791251061348,"version":"4.1.0"},"reference-count":163,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T00:00:00Z","timestamp":1386288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Multiple system atrophy (MSA) is a neurodegenerative disease characterized by the pathological accumulation of alpha\u2010synuclein (\u03b1\u2010syn) within oligodendroglial cells. This accumulation is accompanied by neuroinflammation with astrogliosis and microgliosis, that leads to neuronal death and subsequent parkinsonism and dysautonomia. Antidepressants have been explored as neuroprotective agents as they normalize neurotrophic factor levels, increase neurogenesis and reduce neurodegeneration, but their anti\u2010inflammatory properties have not been fully characterized. We analyzed the anti\u2010inflammatory profiles of three different antidepressants (fluoxetine, olanzapine and amitriptyline) in the MBP1\u2010h\u03b1\u2010syn transgenic (tg) mouse model of MSA. We observed that antidepressant treatment decreased the number of \u03b1\u2010syn\u2010positive cells in the basal ganglia of 11\u2010month\u2010old tg animals. This reduction was accompanied with a similar decrease in the colocalization of \u03b1\u2010syn with astrocyte markers in this brain structure. Consistent with these results, antidepressants reduced astrogliosis in the hippocampus and basal ganglia of the MBP1\u2010h\u03b1\u2010syn tg mice, and modulated the expression levels of key cytokines that were dysregulated in the tg mouse model, such as IL\u20101\u03b2. <jats:italic>In vitro<\/jats:italic> experiments in the astroglial cell line C6 confirmed that antidepressants inhibited NF\u2010\u03baB translocation to the nucleus and reduced IL\u20101\u03b2 protein levels. We conclude that the anti\u2010inflammatory properties of antidepressants in the MBP1\u2010h\u03b1\u2010syn tg mouse model of MSA might be related to their ability to inhibit \u03b1\u2010syn propagation from oligodendrocytes to astroglia and to regulate transcription factors involved in cytokine expression. Our results suggest that antidepressants might be of interest as anti\u2010inflammatory and \u03b1\u2010syn\u2010reducing agents for MSA and other \u03b1\u2010synucleinopathies. GLIA 2014;62:317\u2013337<\/jats:p>","DOI":"10.1002\/glia.22610","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T10:35:03Z","timestamp":1386326103000},"page":"317-337","source":"Crossref","is-referenced-by-count":68,"title":["Antidepressants reduce neuroinflammatory responses and astroglial alpha\u2010synuclein accumulation in a transgenic mouse model of multiple system atrophy"],"prefix":"10.1002","volume":"62","author":[{"given":"Elvira","family":"Valera","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiren","family":"Ubhi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mante","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Rockenstein","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer","family":"Masliah","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego La Jolla California"},{"name":"Department of Pathology University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-10"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.26"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039465"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.9.5337"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-09-03104.2001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1292-12.2012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-09-02945.1996"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.03.023"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-105866"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/609421"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3839.370"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12192-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-013-9413-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0244-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-259"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/383443a0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021660"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35314"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25477"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(80)90051-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10540"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0066-08.2008"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8197455"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0138"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903691106"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.354522"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.080390"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00553.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.10.1901"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22437"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20542"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-47"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0313OC"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-3-5"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7611"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43366"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955711795906888"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152409787601897"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.117"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06795.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.12.019"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00531.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.09.023"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.1.43"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06695.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0672-3"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.04.053"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00226-4"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.7.3513"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90055-K"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400260200"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22700"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046817"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.11.013"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199405030-00005"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.008"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00267.2010"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07933.x"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.03.021"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(00)00026-3"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.03.023"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003597"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00735-0"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.3.4.12809"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0692-05.2005"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.081125"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-551-0_23"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.145"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8267-8"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2005.01683.x"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1746"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6348"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr008"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21899"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.05.111"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.04.033"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1988"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4662"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490310125"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0355"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(95)00011-9"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000336340.89821.b3"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12706-3"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2000.01412.x"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088417"},{"key":"e_1_2_6_89_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3233\/JAD-2009-1158","article-title":"Neuropathology and the neuroinflammation idea","volume":"18","author":"Mrak RE","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10124"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.10.056"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1432.032"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0750576.x"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90219-0"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24978"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027290"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182516244"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283509842"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01661-1"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.053"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3086"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083328"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200504035"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.721466.x"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.7.1233"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199809140-00020"},{"key":"e_1_2_6_108_1","first-page":"271732","article-title":"Neuroinflammation in Parkinson's disease and related disorders: A lesson from genetically manipulated mouse models of \u03b1\u2010synucleinopathies","volume":"2012","author":"Sekiyama K","year":"2012","journal-title":"Parkinsons Dis"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-7"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31450"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00181-1"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3527-05.2005"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090278"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.10.004"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1202263"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412139200"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(99)00031-0"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00504-7"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.07.002"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-1-14"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00444-1"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v21.i5.20"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.12.006"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31819fccd5"},{"key":"e_1_2_6_125_1","first-page":"367","article-title":"Abnormal accumulation of NACP\/alpha\u2010synuclein in neurodegenerative disorders","volume":"152","author":"Takeda A","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0259-4"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01393-9"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.12.4435.bloodjournal88124435"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fd613b"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025406"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070690"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.01.008"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0567-10.2010"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00486.2002"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3282ee2a91"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1159\/000317064"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0102398"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050918"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2006.00713.x"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00407-8"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00384-0"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3632-07.2008"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.07.005"},{"key":"e_1_2_6_144_1","first-page":"1070","article-title":"Progression and prognosis in multiple system atrophy: An analysis of 230 Japanese patients","volume":"5","author":"Watanabe H","year":"2002","journal-title":"Brain 125 (Part"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.06.025"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.12286"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0935-y"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100976108"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.11.1155"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2723-12.2012"},{"key":"e_1_2_6_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.12.016"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.01.009"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00794-8"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-04-01436.2002"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.032"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00841.x"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334095"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-8-82"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-010-8098-4"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(11)70066-9"},{"key":"e_1_2_6_161_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2751com"},{"key":"e_1_2_6_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06263.x"},{"key":"e_1_2_6_163_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057307"},{"key":"e_1_2_6_164_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.10.16520"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.22610","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.22610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:16:34Z","timestamp":1696389394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.22610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,6]]},"references-count":163,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/glia.22610"],"URL":"https:\/\/doi.org\/10.1002\/glia.22610","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,6]]}}}