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The GFAP immunoreaction was subtype specific. In aged and AD cerebella, different morphological and GFAP\u2010immunoreactive subtype\u2010specific changes were observed: in the white matter, the subtypes were always GFAP\u2010immunopositive, but in the grey matter some astroglial subtypes showed a variable or no increase in GFAP staining. The astrocytes at the limits of the granule cell layer showed more and longer processes. Variations were seen in one or more folia, involving one or more subtypes and affecting different numbers of cells of each subtype. No clear differences were seen in glial reactivity between beta\u2010amyloid positive and \u03b2\u2010amyloid (A\u03b2) negative AD cerebella. No important relationships were found between A\u03b2 deposits. In aged and AD cerebella, different subtypes expressed new proteins (APP, calretinin). <jats:italic>Conclusions<\/jats:italic> The existence of different glial subtypes in different locations suggests they have different functions. General and local variations in these subtypes suggest that both general and local induction factors must also exist. The responses of glial cells to as\u2010yet undefined stimuli might lead to general or local neuronal changes important in senility and the pathogenic course of AD. 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