{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:26:36Z","timestamp":1790508396370,"version":"4.1.0"},"reference-count":125,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Stroke and spinal cord injury (SCI) are among the most frequent causes of central nervous system (CNS) dysfunction, affecting millions of people worldwide each year. The personal and financial costs for affected individuals, their families, and the broader communities are enormous. Although the mammalian CNS exhibits little spontaneous regeneration and self\u2010repair, recent discoveries have revealed that subpopulations of glial cells in the adult forebrain subventricular zone and the spinal cord ependymal zone possess neural stem cell properties. These endogenous neural stem cells react to stroke and SCI by contributing a significant number of new neural cells to formation of the glial scar. These findings have raised hopes that new therapeutic strategies can be designed based on appropriate modulation of endogenous neural stem cell responses to CNS injury. Here, we review the responses of forebrain and spinal cord neural stem cells to stroke and SCI, the role of these responses in restricting injury\u2010induced tissue loss, and the possibility of directing these responses to promote anatomical and functional repair of the CNS. GLIA 2015;63:1469\u20131482<\/jats:p>","DOI":"10.1002\/glia.22851","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T11:16:12Z","timestamp":1430306172000},"page":"1469-1482","source":"Crossref","is-referenced-by-count":145,"title":["Endogenous neural stem cell responses to stroke and spinal cord injury"],"prefix":"10.1002","volume":"63","author":[{"given":"Catherine\u2010Alexandra","family":"Gr\u00e9goire","sequence":"first","affiliation":[{"name":"Research Center of the University of Montreal Hospital (CRCHUM) Quebec Canada"},{"name":"CNS Research Group (GRSNC), University of Montreal Quebec Canada"},{"name":"Department of Pathology and Cell Biology, Faculty of Medicine Universit\u00e9 De Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna L.","family":"Goldenstein","sequence":"additional","affiliation":[{"name":"Research Center of the University of Montreal Hospital (CRCHUM) Quebec Canada"},{"name":"CNS Research Group (GRSNC), University of Montreal Quebec Canada"},{"name":"Department of Neurosciences, Faculty of Medicine Universit\u00e9 De Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa M.","family":"Floriddia","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanie","family":"Barnab\u00e9\u2010Heider","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J. L.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Research Center of the University of Montreal Hospital (CRCHUM) Quebec Canada"},{"name":"CNS Research Group (GRSNC), University of Montreal Quebec Canada"},{"name":"Department of Neurosciences, Faculty of Medicine Universit\u00e9 De Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02301"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2003.08.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.07.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22421"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90015-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.04.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","unstructured":"BayraktarOA FuentealbaLC Alvarez\u2010BuyllaA RowitchDH.2014.Astrocyte development and heterogeneity.Cold Spring Harb Perspect Biol. 7 a020362.","DOI":"10.1101\/cshperspect.a020362"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12069"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07832.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/378498a0"},{"key":"e_1_2_6_13_1","first-page":"55","article-title":"Ependyma of the central canal of the rat spinal cord: A light and transmission electron microscopic study","volume":"152","author":"Bruni JE.","year":"1987","journal-title":"J Anat"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709002105"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6239-09.2010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2268"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000219"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.91"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0076"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.12.024"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3053"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/37776"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-05810.1999"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121807"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80783-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21646"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC\/2008\/24\/3-4\/E18"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.05.018"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3547-03.2004"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.06.018"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8290-9"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.05.014"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.2.453"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-7-13"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2012_228"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0758-12.2012"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.119"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203165"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7628"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2010.07.003"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.09.006"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2568-14.2015"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1405"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21065"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-06-02218.2000"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.2741\/3734"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.07.004"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081011098"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00159-3"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80956-3"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-28-09276.2003"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612053507468"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.13.55"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.11.002"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3257-09.2009"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.01.018"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3163"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600402"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01146.x"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135600"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085916"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.002"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15022207"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22406"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.02.030"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00657-8"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.11.016"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22723"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.84"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0224-08.2008"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05390.x"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.346.6206.237"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02181.x"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116738109"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90247-X"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060182"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533187100"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1299-06.2006"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.004"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.10.011"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027079"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00993263"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1425"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2736"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31829734f2"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10393"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21149"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7118"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0002-12.2012"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210293110"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771501750055794"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00488.x"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20798"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1553558"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2591"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC.2008.25.11.E2"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.01.026"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242576"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4130"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1326"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.01.019"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90045-8"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10736"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2707"},{"key":"e_1_2_6_106_1","unstructured":"The National Spinal Cord Injury Statistical Center.2013. Spinal cord injury facts and figures at a glance. Available at:www.uab.edu\/nscisc. Accessed October 7th 2014."},{"key":"e_1_2_6_107_1","unstructured":"World Health Organization.2002. World Health Report 2002. Available at:http:\/\/www.who.int\/whr\/2002\/en\/. Accessed October 5th 2014."},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20604"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.6.1120"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902890106"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-003-0364-2"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5524-09.2011"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-23-07599.1996"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.3.444"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(98)90240-4"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22282"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0149-06.2006"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20176"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.04.007"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200404000-00009"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1109-04.2004"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113972"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4969-06.2007"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600430"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00117-8"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2510-13.2013"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.22851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.22851","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.22851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.22851","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.22851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:29:38Z","timestamp":1692642578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.22851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,29]]},"references-count":125,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/glia.22851"],"URL":"https:\/\/doi.org\/10.1002\/glia.22851","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,29]]}}}