{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:22:33Z","timestamp":1790176953324,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":34,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"crossref","award":["R19-A2105 and R77-A6808"],"award-info":[{"award-number":["R19-A2105 and R77-A6808"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Carlsberg Foundation and the Danish Medical Research Council","award":["09-063399"],"award-info":[{"award-number":["09-063399"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1002\/glia.22895","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T15:15:16Z","timestamp":1438182916000},"page":"2313-2326","source":"Crossref","is-referenced-by-count":72,"title":["Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes"],"prefix":"10.1002","volume":"63","author":[{"given":"Jakob D.","family":"Nissen","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla","family":"Paj\u0119cka","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin H.","family":"Stridh","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte M.","family":"Skytt","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle S.","family":"Waagepetersen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"10.1002\/glia.22895-BIB0001|glia22895-cit-0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1098-1136(200010)32:1<1::AID-GLIA10>3.0.CO;2-W","article-title":"Astrocyte glutamate transport: Review of properties, regulation, and physiological functions","volume":"32","author":"Anderson","year":"2000","journal-title":"Glia"},{"key":"10.1002\/glia.22895-BIB0002|glia22895-cit-0002","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jnr.490180207","article-title":"Glial glutamate dehydrogenase: Ultrastructural localization and regional distribution in relation to the mitochondrial enzyme, cytochrome oxidase","volume":"18","author":"Aoki","year":"1987","journal-title":"J Neurosci Res"},{"key":"10.1002\/glia.22895-BIB0003|glia22895-cit-0003","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/sj.jcbfm.9600281","article-title":"Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons","volume":"26","author":"Bak","year":"2006","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1002\/glia.22895-BIB0004|glia22895-cit-0004","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1097\/00001756-199705060-00004","article-title":"[U-13C]glutamate metabolism in rat brain mitochondria reveals malic enzyme activity","volume":"8","author":"Bakken","year":"1997","journal-title":"Neuroreport"},{"key":"10.1002\/glia.22895-BIB0005|glia22895-cit-0005","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.neuint.2012.01.013","article-title":"The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism","volume":"61","author":"Bauer","year":"2012","journal-title":"Neurochem Int"},{"key":"10.1002\/glia.22895-BIB0006|glia22895-cit-0006","first-page":"205","volume-title":"Glutamine, glutamate and GABA in the central nervous system","author":"Berl","year":"1983"},{"key":"10.1002\/glia.22895-BIB0007|glia22895-cit-0007","first-page":"223","volume-title":"Mass spectrometry. organic chemistry applications","author":"Biemann","year":"1962"},{"key":"10.1002\/glia.22895-BIB0008|glia22895-cit-0008","doi-asserted-by":"crossref","first-page":"12916","DOI":"10.1016\/S0021-9258(19)38247-X","article-title":"Cerebral metabolism of [1,2-13C2]acetate as detected by in vivo and in vitro 13C NMR","volume":"265","author":"Cerdan","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.22895-BIB0009|glia22895-cit-0009","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1046\/j.1471-4159.1998.70062613.x","article-title":"Ontogeny and cellular localization of the pyruvate recycling system in rat brain","volume":"70","author":"Cruz","year":"1998","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0010|glia22895-cit-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog Neurobiol"},{"key":"10.1002\/glia.22895-BIB0011|glia22895-cit-0011","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/glia.20157","article-title":"Astrocytic contributions to bioenergetics of cerebral ischemia","volume":"50","author":"Dienel","year":"2005","journal-title":"Glia"},{"key":"10.1002\/glia.22895-BIB0012|glia22895-cit-0012","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00125-009-1590-6","article-title":"Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism","volume":"53","author":"Frigerio","year":"2010","journal-title":"Diabetologia"},{"key":"10.1002\/glia.22895-BIB0062|glia22895-cit-0062","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1471-4159.2012.07933.x","article-title":"Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission","volume":"123","author":"F","year":"2012","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0013|glia22895-cit-0013","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1124\/mol.52.1.6","article-title":"High affinity glutamate transporters: Regulation of expression and activity","volume":"52","author":"Gegelashvili","year":"1997","journal-title":"Mol Pharmacol"},{"key":"10.1002\/glia.22895-BIB0014|glia22895-cit-0014","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0361-9230(97)00417-6","article-title":"Cellular distribution and kinetic properties of high-affinity glutamate transporters","volume":"45","author":"Gegelashvili","year":"1998","journal-title":"Brain Res Bull"},{"key":"10.1002\/glia.22895-BIB0015|glia22895-cit-0015","doi-asserted-by":"crossref","first-page":"18275","DOI":"10.1523\/JNEUROSCI.3305-11.2011","article-title":"Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria","volume":"31","author":"Genda","year":"2011","journal-title":"J Neurosci"},{"key":"10.1002\/glia.22895-BIB0016|glia22895-cit-0016","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0301-0082(79)90018-2","article-title":"Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters","volume":"13","author":"Hertz","year":"1979","journal-title":"Prog Neurobiol"},{"key":"10.1002\/glia.22895-BIB0017|glia22895-cit-0017","first-page":"105","volume-title":"A Dissection and tissue culture manual of the nervous system","author":"Hertz","year":"1989"},{"key":"10.1002\/glia.22895-BIB0018|glia22895-cit-0018","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuint.2011.05.001","article-title":"Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways","volume":"59","author":"Hutson","year":"2011","journal-title":"Neurochem Int"},{"key":"10.1002\/glia.22895-BIB0019|glia22895-cit-0019","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1159\/000017335","article-title":"In vitro and ex vivo 13C-NMR spectroscopy studies of pyruvate recycling in brain","volume":"20","author":"H\u00e5berg","year":"1998","journal-title":"Dev Neurosci"},{"key":"10.1002\/glia.22895-BIB0020|glia22895-cit-0020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1074\/jbc.M109.048777","article-title":"Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm)","volume":"285","author":"Islam","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.22895-BIB0021|glia22895-cit-0021","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.neuint.2007.01.009","article-title":"The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes","volume":"50","author":"Johansen","year":"2007","journal-title":"Neurochem Int"},{"key":"10.1002\/glia.22895-BIB0022|glia22895-cit-0022","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s11064-013-1173-2","article-title":"Glutamate dehydrogenase: Structure, allosteric regulation, and role in insulin homeostasis","volume":"39","author":"Li","year":"2014","journal-title":"Neurochem Res"},{"key":"10.1002\/glia.22895-BIB0023|glia22895-cit-0023","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.22895-BIB0024|glia22895-cit-0024","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jnr.20353","article-title":"Molecular basis of human glutamate dehydrogenase regulation under changing energy demands","volume":"79","author":"Mastorodemos","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1002\/glia.22895-BIB0025|glia22895-cit-0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0021-9673(01)90333-4","article-title":"Analysis of amino acids as their tert.-butyldimethylsilyl derivatives by gas-liquid chromatography and mass spectrometry","volume":"358","author":"Mawhinney","year":"1986","journal-title":"J Chromatogr"},{"key":"10.1002\/glia.22895-BIB0026|glia22895-cit-0026","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.neuint.2005.11.018","article-title":"Aspartate aminotransferase in synaptic and nonsynaptic mitochondria: Differential effect of compounds that influence transient hetero-enzyme complex (metabolon) formation","volume":"48","author":"McKenna","year":"2006","journal-title":"Neurochem Int"},{"key":"10.1002\/glia.22895-BIB0027|glia22895-cit-0027","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1046\/j.1471-4159.1996.66010386.x","article-title":"Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes","volume":"66","author":"McKenna","year":"1996a","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0028|glia22895-cit-0028","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0197-0186(00)00042-5","article-title":"Differential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminals","volume":"37","author":"McKenna","year":"2000a","journal-title":"Neurochem Int"},{"key":"10.1002\/glia.22895-BIB0029|glia22895-cit-0029","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0197-0186(99)00148-5","article-title":"Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells","volume":"36","author":"McKenna","year":"2000b","journal-title":"Neurochem Int"},{"key":"10.1002\/glia.22895-BIB0030|glia22895-cit-0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000111431","article-title":"New insights into the compartmentation of glutamate and glutamine in cultured rat brain astrocytes","volume":"18","author":"McKenna","year":"1996b","journal-title":"Dev Neurosci"},{"key":"10.1002\/glia.22895-BIB0031|glia22895-cit-0031","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/BF00970599","article-title":"Regulation of mitochondrial and cytosolic malic enzymes from cultured rat brain astrocytes","volume":"20","author":"McKenna","year":"1995","journal-title":"Neurochem Res"},{"key":"10.1002\/glia.22895-BIB0032|glia22895-cit-0032","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fendo.2013.00191","article-title":"Glutamate pays its own way in astrocytes","volume":"4","author":"McKenna","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1002\/glia.22895-BIB0033|glia22895-cit-0033","first-page":"224","volume-title":"Energy metabolism of the brain","author":"McKenna","year":"2012"},{"key":"10.1002\/glia.22895-BIB0034|glia22895-cit-0034","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1002\/jnr.21208","article-title":"Pyruvate recycling in cultured neurons from cerebellum","volume":"85","author":"Olstad","year":"2007","journal-title":"J Neurosci Res"},{"key":"10.1002\/glia.22895-BIB0035|glia22895-cit-0035","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/jnr.23568","article-title":"Glucose replaces glutamate as energy substrate to fuel glutamate uptake in glutamate dehydrogenase deficient astrocytes","volume":"93","author":"Paj\u0119cka","year":"2015","journal-title":"J Neurosci Res"},{"key":"10.1002\/glia.22895-BIB0036|glia22895-cit-0036","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1471-4159.1974.tb04285.x","article-title":"The relative significance of CO2-fixing enzymes in the metabolism of rat brain","volume":"22","author":"Patel","year":"1974","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0037|glia22895-cit-0037","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1471-4159.1988.tb10586.x","article-title":"Regulation of transmitter gamma-aminobutyric acid (GABA) synthesis and metabolism illustrated by the effect of gamma-vinyl GABA and hypoglycemia","volume":"50","author":"Paulsen","year":"1988","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0038|glia22895-cit-0038","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1046\/j.1471-4159.2000.0751862.x","article-title":"Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function","volume":"75","author":"Plaitakis","year":"2000","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0039|glia22895-cit-0039","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jnr.10054","article-title":"Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain","volume":"66","author":"Plaitakis","year":"2001","journal-title":"J Neurosci Res"},{"key":"10.1002\/glia.22895-BIB0040|glia22895-cit-0040","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/0306-4522(94)90349-2","article-title":"Quantitative ultrastructural localization of glutamate dehydrogenase in the rat cerebellar cortex","volume":"62","author":"Rothe","year":"1994","journal-title":"Neuroscience"},{"key":"10.1002\/glia.22895-BIB0041|glia22895-cit-0041","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0306-4522(90)90278-C","article-title":"Immunohistochemical demonstration of glutamate dehydrogenase in the postnatally developing rat hippocampal formation and cerebellar cortex: Comparison to activity staining","volume":"39","author":"Rothe","year":"1990","journal-title":"Neuroscience"},{"key":"10.1002\/glia.22895-BIB0042|glia22895-cit-0042","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-319-08894-5_2","article-title":"Glutamate metabolism in the brain focusing on astrocytes","volume":"11","author":"Schousboe","year":"2014","journal-title":"Adv Neurobiol"},{"key":"10.1002\/glia.22895-BIB0043|glia22895-cit-0043","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000111356","article-title":"Glutamate and glutamine metabolism and compartmentation in astrocytes","volume":"15","author":"Schousboe","year":"1993","journal-title":"Dev Neurosci"},{"key":"10.1002\/glia.22895-BIB0044|glia22895-cit-0044","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0006-8993(85)90552-9","article-title":"Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools","volume":"329","author":"Shank","year":"1985","journal-title":"Brain Res"},{"key":"10.1002\/glia.22895-BIB0045|glia22895-cit-0045","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s11064-013-1227-5","article-title":"The discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and disease","volume":"39","author":"Shashidharan","year":"2014","journal-title":"Neurochem Res"},{"key":"10.1002\/glia.22895-BIB0046|glia22895-cit-0046","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.neuint.2012.04.014","article-title":"siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate","volume":"61","author":"Skytt","year":"2012","journal-title":"Neurochem Int"},{"key":"10.1002\/glia.22895-BIB0047|glia22895-cit-0047","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/jnc.12812","article-title":"Glutamate synthesis has to be matched by its degradation - Where do all the carbons go?","volume":"131","author":"Sonnewald","year":"2014","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0048|glia22895-cit-0048","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1014846404492","article-title":"Metabolic compartmentation in cortical synaptosomes: influence of glucose and preferential incorporation of endogenous glutamate into GABA","volume":"27","author":"Sonnewald","year":"2002","journal-title":"Neurochem Res"},{"key":"10.1002\/glia.22895-BIB0049|glia22895-cit-0049","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1046\/j.1471-4159.1996.67062566.x","article-title":"Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: First evidence of astrocytic pyruvate recycling","volume":"67","author":"Sonnewald","year":"1996","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0050|glia22895-cit-0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/(SICI)1098-1136(199709)21:1<56::AID-GLIA6>3.0.CO;2-#","article-title":"Glutamate transport and metabolism in astrocytes","volume":"21","author":"Sonnewald","year":"1997","journal-title":"Glia"},{"key":"10.1002\/glia.22895-BIB0051|glia22895-cit-0051","doi-asserted-by":"crossref","first-page":"16748","DOI":"10.1074\/jbc.M109.092999","article-title":"Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells","volume":"285","author":"Spanaki","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.22895-BIB0052|glia22895-cit-0052","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2174\/157340608784872235","article-title":"Truncation of the Krebs cycle during hypoglycemic coma","volume":"4","author":"Sutherland","year":"2008","journal-title":"Med Chem"},{"key":"10.1002\/glia.22895-BIB0053|glia22895-cit-0053","doi-asserted-by":"crossref","first-page":"19486","DOI":"10.1016\/S0021-9258(17)45399-3","article-title":"Interactions among mitochondrial aspartate aminotransferase, malate dehydrogenase, and the inner mitochondrial membrane from heart, hepatoma, and liver","volume":"265","author":"Teller","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1002\/glia.22895-BIB0054|glia22895-cit-0054","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/bj1230211","article-title":"A stimulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain","volume":"123","author":"den Berg","year":"1971","journal-title":"Biochem J"},{"key":"10.1002\/glia.22895-BIB0055|glia22895-cit-0055","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/(SICI)1098-1136(199606)17:2<160::AID-GLIA7>3.0.CO;2-6","article-title":"Evaluation of the importance of transamination versus deamination in astrocytic metabolism of [U-13C]glutamate","volume":"17","author":"Westergaard","year":"1996","journal-title":"Glia"},{"key":"10.1002\/glia.22895-BIB0056|glia22895-cit-0056","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0305-0491(91)90378-Q","article-title":"The intracellular distribution and activities of phosphoenolpyruvate carboxykinase isozymes in various tissues of several mammals and birds","volume":"100","author":"Wiese","year":"1991","journal-title":"Comp Biochem Physiol B Comp Biochem"},{"key":"10.1002\/glia.22895-BIB0057|glia22895-cit-0057","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1023\/A:1021636102735","article-title":"Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons","volume":"27","author":"Waagepetersen","year":"2002","journal-title":"Neurochem Res"},{"key":"10.1002\/glia.22895-BIB0058|glia22895-cit-0058","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1073\/pnas.47.7.983","article-title":"An effect of L-leucine and other essential amino acids on the structure and activity of glutamic dehydrogenase","volume":"47","author":"Yielding","year":"1961","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/glia.22895-BIB0059|glia22895-cit-0059","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1471-4159.1982.tb11482.x","article-title":"Metabolic fate of 14C-labeled glutamate in astrocytes in primary cultures","volume":"39","author":"Yu","year":"1982","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0060|glia22895-cit-0060","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/j.1471-4159.1983.tb00849.x","article-title":"Pyruvate carboxylase activity in primary cultures of astrocytes and neurons","volume":"41","author":"Yu","year":"1983","journal-title":"J Neurochem"},{"key":"10.1002\/glia.22895-BIB0061|glia22895-cit-0061","doi-asserted-by":"crossref","first-page":"27414","DOI":"10.1016\/S0021-9258(18)47001-9","article-title":"Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate\/aspartate shuttle","volume":"269","author":"Yudkoff","year":"1994","journal-title":"J Biol Chem"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.22895","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/glia.22895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T12:32:44Z","timestamp":1652963564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.22895"}},"subtitle":["Role of Glutamate Dehydrogenase in Astrocytes"],"short-title":[],"issued":{"date-parts":[[2015,7,29]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.1002\/glia.22895","archive":["Portico"],"relation":{},"ISSN":["0894-1491"],"issn-type":[{"value":"0894-1491","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7,29]]}}}