{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:35:42Z","timestamp":1776476142807,"version":"3.51.2"},"reference-count":131,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["DFG WE2720\/2-1 to H.B.W."],"award-info":[{"award-number":["DFG WE2720\/2-1 to H.B.W."]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["MA1053\/6-1 to R.M.; 1944\/1-1 to M.W.S"],"award-info":[{"award-number":["MA1053\/6-1 to R.M.; 1944\/1-1 to M.W.S"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Research Council, Advanced Grand to K.-A. N"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Protein zero (P0) is the major structural component of peripheral myelin. Lack of this adhesion protein from Schwann cells causes a severe dysmyelinating neuropathy with secondary axonal degeneration in humans with the neuropathy Dejerine\u2010Sottas syndrome (DSS) and in the corresponding mouse model (<jats:italic>P0<jats:sup>null<\/jats:sup><\/jats:italic>\u2010mice). In the mammalian CNS, the tetraspan\u2010membrane protein PLP is the major structural myelin constituent and required for the long\u2010term preservation of myelinated axons, which fails in hereditary spastic paraplegia (SPG type\u20102) and the relevant mouse model (<jats:italic>Plp<jats:sup>null<\/jats:sup><\/jats:italic>\u2010mice). The <jats:italic>Plp<\/jats:italic>\u2010gene is also expressed in Schwann cells but PLP is of very low abundance in normal peripheral myelin; its function has thus remained enigmatic. Here we show that the abundance of PLP but not of other tetraspan myelin proteins is strongly increased in compact peripheral myelin of <jats:italic>P0<jats:sup>null<\/jats:sup><\/jats:italic>\u2010mice. To determine the functional relevance of PLP expression in the absence of P0, we generated <jats:italic>P0<jats:sup>null<\/jats:sup><\/jats:italic>*<jats:italic>Plp<jats:sup>null<\/jats:sup><\/jats:italic>\u2010double\u2010mutant mice. Compared with either single\u2010mutant, <jats:italic>P0<jats:sup>null<\/jats:sup><\/jats:italic>*<jats:italic>Plp<jats:sup>null<\/jats:sup><\/jats:italic>\u2010mice display impaired nerve conduction, reduced motor functions, and premature death. At the morphological level, axonal segments were frequently non\u2010myelinated but in a one\u2010to\u2010one relationship with a hypertrophic Schwann cell. Importantly, axonal numbers were reduced in the vital phrenic nerve of <jats:italic>P0<jats:sup>null<\/jats:sup><\/jats:italic>*<jats:italic>Plp<jats:sup>null<\/jats:sup><\/jats:italic>\u2010mice. In the absence of P0, thus, PLP also contributes to myelination by Schwann cells and to the preservation of peripheral axons. These data provide a link between the Schwann cell\u2010dependent support of peripheral axons and the oligodendrocyte\u2010dependent support of central axons. GLIA 2016;64:155\u2013174<\/jats:p>","DOI":"10.1002\/glia.22922","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T21:29:24Z","timestamp":1442957364000},"page":"155-174","source":"Crossref","is-referenced-by-count":24,"title":["Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking"],"prefix":"10.1002","volume":"64","author":[{"given":"Julia","family":"Patzig","sequence":"first","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Kusch","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fledrich","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Eichel","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja A.","family":"L\u00fcders","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"M\u00f6bius","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"},{"name":"Center for Nanoscale Microscopy and Molecular Physiology of the Brain G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Sereda","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"},{"name":"Department of Clinical Neurophysiology University Medical Center G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2010Armin","family":"Nave","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Neurology Developmental Neurobiology, University Hospital W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke B.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute of Experimental Medicine G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-006-0053-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19971001)50:1<13::AID-JNR2>3.0.CO;2-O"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980518)394:4<506::AID-CNE8>3.0.CO;2-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490350107"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3809"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20386"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.09.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01870.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-05-01772.2002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051035"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.12.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.2.301"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199909)27:3<203::AID-GLIA2>3.0.CO;2-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199912)28:3<256::AID-GLIA9>3.0.CO;2-O"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153248"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90057-M"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.2.281"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-0958-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22561"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90183-D"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05288.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.10.011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200202124"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312012"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.08.003"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/344871a0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.10.012"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-06058.1999"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb00347.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6182-8"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08597.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80360-8"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf043"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf475"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90591-Y"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201503019"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.08.007"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5369.1610"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq269"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22796"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr283"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.5.e95"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490350511"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5274.507"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-266-7_15"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8071-2"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020487"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-24-07920.1996"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90358-1"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0267-y"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv240"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)80046-5"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg072"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00237.1998"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512159200"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90198-9"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/369747a0"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21051"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2273"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00257.x"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20385"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1027"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20766"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.06.002"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-06-04488.1995"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199704)19:4<298::AID-GLIA3>3.0.CO;2-U"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-281"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200705132"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.07.007"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.12.006"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(10)96020-2"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X0900009X"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22852"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90472-3"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.07.018"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi801302b"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.08.008"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013101"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3955-08.2009"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22520"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5204-08.2009"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4016-11.2011"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-010-0158-7"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.9.3198-3209.2000"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.12.021"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.4.1218"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.01.005"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.5.1035"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.03.001"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00247.x"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90214-3"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200402087"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20750"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-07-02833.2003"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv241"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws140"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0394-257"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200406092"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20751"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-02-00729.2000"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.11.015"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10466"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0562-8"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401498"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-004-6882-0"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1915"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10014"},{"key":"e_1_2_6_109_1","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1523\/JNEUROSCI.20-11-04002.2000","article-title":"The evolution of lipophilin genes from invertebrates to tetrapods: DM\u201020 cannot replace proteolipid protein in CNS myelin","volume":"20","author":"Stecca B","year":"2000","journal-title":"J Neurosci"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.07.014"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20767"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3216-08.2009"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20100016"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.37"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/371796a0"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3825"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10762"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181efa658"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.012"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb42377.x"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1998.tb00200.x"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22456"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1254-07.2007"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3819-05.2006"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.5.1021"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20000615)60:6<714::AID-JNR3>3.0.CO;2-1"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200509174"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-01953.1998"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.5.1009"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22733"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20010115)63:2<151::AID-JNR1007>3.0.CO;2-Y"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80138-5"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.22922","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.22922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:11:11Z","timestamp":1696367471000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.22922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":131,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/glia.22922"],"URL":"https:\/\/doi.org\/10.1002\/glia.22922","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,22]]}}}