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It remains unclear, however, whether the cellular crosstalk between fibroblasts and Schwann cells (SCs) is related to phenotype modulation of SCs, a critical cellular process after peripheral nerve injury. In this study, microarray analysis revealed that a total of 6,046 genes were differentially expressed in the proximal nerve segment after sciatic nerve transection in rats, and bioinformatics analysis further identified tenascin\u2010C (TNC), an extracellular matrix (ECM) protein, as a key gene regulator. TNC was abundantly produced by nerve fibroblasts accumulating at the lesion site, rather than by SCs as usually expected. TNC significantly promoted SC migration without effects on SC proliferation in primary culture. In co\u2010culture of fibroblasts and SCs, inhibition of TNC expression either by siRNA transfection or antibody blockade could suppress SC migration, while TNC\u2010stimulated SC migration was mediated by TNC binding to \u03b21\u2010integrin receptor in SCs through activation of Rac1 effectors. The <jats:italic>in vivo<\/jats:italic> evidence showed that exogenous TNC protein enhanced SC migration and axonal regrowth. Our results highlight that TNC\u2010mediated cellular interaction between fibroblasts and SCs may regulate SC migration through \u03b21\u2010integrin\u2010dependent pathway during peripheral nerve regeneration. GLIA 2016;64:374\u2013385<\/jats:p>","DOI":"10.1002\/glia.22934","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T01:05:11Z","timestamp":1445735111000},"page":"374-385","source":"Crossref","is-referenced-by-count":74,"title":["Fibroblast\u2010derived tenascin\u2010<scp>C<\/scp> promotes <scp>S<\/scp>chwann cell migration through \u03b21\u2010integrin dependent pathway during peripheral nerve regeneration"],"prefix":"10.1002","volume":"64","author":[{"given":"Zhanhu","family":"Zhang","sequence":"first","affiliation":[{"name":"Model Animal Research Center, Nanjing University Nanjing China"},{"name":"Jiangsu Key Laboratory of Neuroregeneration Co\u2010Innovation Center of Neuroregeneration, Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration Co\u2010Innovation Center of Neuroregeneration, Nantong 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