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Given the localization of the protein Dp71 around the retinal vessels in adult mice and its role in maintaining retinal homeostasis, the aim of this study was to determine if Dp71 was involved in astrocyte and vascular development regulation. An experimental study in mouse retinas was conducted. Using a dual immunolabeling with antibodies to Dp71 and anti\u2010GFAP for astrocytes on retinal sections and isolated astrocytes, it was found that Dp71 was expressed in wild\u2010type (WT) mouse astrocytes from early developmental stages to adult stage. In Dp71\u2010null mice, a reduction in GFAP\u2010immunopositive astrocytes was observed as early as postnatal day 6 (P6) compared with WT mice. Using real\u2010time PCR, it was showed that Dp71 mRNA was stable between P1 and P6, in parallel with post\u2010natal vascular development. Regarding morphology in Dp71\u2010null and WT mice, a significant decrease in overall astrocyte process number in Dp71\u2010null retinas at P6 to adult age was found. Using fluorescence\u2010conjugated isolectin <jats:italic>Griffonia simplicifolia<\/jats:italic> on whole mount retinas, subsequent delay of developing vascular network at the same age in Dp71\u2010null mice was found. An evidence that the Dystrophin Dp71, a membrane\u2010associated cytoskeletal protein and one of the smaller <jats:italic>Duchenne muscular dystrophy<\/jats:italic> gene products, regulates astrocyte morphology and density and is associated with subsequent normal blood vessel development was provided. GLIA 2016;64:716\u2013729<\/jats:p>","DOI":"10.1002\/glia.22956","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T11:03:23Z","timestamp":1451387003000},"page":"716-729","source":"Crossref","is-referenced-by-count":33,"title":["Altered astrocyte morphology and vascular development in dystrophin\u2010<scp>D<\/scp>p71\u2010null mice"],"prefix":"10.1002","volume":"64","author":[{"given":"Audrey","family":"Giocanti\u2010Auregan","sequence":"first","affiliation":[{"name":"Ophthalmology Department Avicenne Hospital 125 Rue De Stalingrad Bobigny France"},{"name":"Institut De La Vision Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S, 968 Paris F\u201075012 France"},{"name":"INSERM, U_968 Paris F\u201075012 France"},{"name":"CNRS, UMR_7210 Paris F\u201075012 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oph\u00e9lie","family":"Vacca","sequence":"additional","affiliation":[{"name":"Institut De La Vision Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S, 968 Paris F\u201075012 France"},{"name":"INSERM, U_968 Paris F\u201075012 France"},{"name":"CNRS, UMR_7210 Paris F\u201075012 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"B\u00e9nard","sequence":"additional","affiliation":[{"name":"Institut De La Vision Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S, 968 Paris F\u201075012 France"},{"name":"INSERM, U_968 Paris F\u201075012 France"},{"name":"CNRS, UMR_7210 Paris F\u201075012 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Cao","sequence":"additional","affiliation":[{"name":"Institut De La Vision Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S, 968 Paris F\u201075012 France"},{"name":"INSERM, U_968 Paris F\u201075012 France"},{"name":"CNRS, UMR_7210 Paris F\u201075012 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Siqueiros","sequence":"additional","affiliation":[{"name":"Institut De La Vision Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S, 968 Paris F\u201075012 France"},{"name":"INSERM, U_968 Paris F\u201075012 France"},{"name":"CNRS, UMR_7210 Paris F\u201075012 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Monta\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Genetics &amp; Molecular Biology Research Centre for Advanced Studies, IPN Av. 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