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In thick sections immunolabeled for HLA\u2010DR or Iba\u20101 dystrophic microglial processes lose their typical, homogeneous staining pattern and appear to be fragmented or clustered. In this study, we performed double immunofluorescence and electron microscopy to determine if this labeling pattern indeed reflects complete separation of microglial processes from the soma. Using Iba\u20101\/CD68 and Iba\u20101\/MHC class II, as microglial markers, we observed that isolated Iba\u20101 fragments were still connected to each other by segments of the microglial process immune positive for CD68 or MHC class II. Ultrathin serial sections of two Iba\u20101 fragments which appeared to be disconnected from each other at the light microscopical level revealed a still existing \"bridge\" with a diameter of around 0.182 \u00b5m. Therefore, microglial dystrophy may reflect alterations of the cytoskeleton ultimately leading to slow cytorrhexis. 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