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NTE\/PNPLA6 is widely expressed in neurons but experiments with its\n                    <jats:italic>Drosophila<\/jats:italic>\n                    orthologue Swiss\u2010cheese (SWS) suggested that it may also have glial functions. Investigating whether NTE\/PNPLA6 is expressed in glia, we found that NTE\/PNPLA6 is expressed by Schwann cells in the sciatic nerve of adult mice with the most prominent expression in nonmyelinating Schwann cells. Within Schwann cells, NTE\/PNPLA6 is enriched at the Schmidt\u2010Lanterman incisures and around the nucleus. When analyzing postnatal expression patterns, we did not detect NTE\/PNPLA6 in promyelinating Schwann cells, while weak expression was detectable at postnatal day 5 in Schwann cells and increased with their maturation. Interestingly, NTE\/PNPLA6 levels were upregulated after nerve crush and localized to ovoids forming along the nerve fibers. Using a GFAP\u2010based knock\u2010out of NTE\/PNPLA6, we detected an incomplete ensheathment of Remak fibers whereas myelination did not appear to be affected. These results suggest that NTE\/PNPLA6 is involved in the maturation of nonmyelinating Schwann cells during development and de\u2010\/remyelination after neuronal injury. Since Schwann cells play an important role in maintaining axonal viability and function, it is therefore likely that changes in Schwann cells contribute to the locomotory deficits and neuropathy observed in patients carrying mutations in NTE.\n                  <\/jats:p>","DOI":"10.1002\/glia.23127","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T08:27:08Z","timestamp":1487233628000},"page":"804-816","source":"Crossref","is-referenced-by-count":36,"title":["NTE\/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers"],"prefix":"10.1002","volume":"65","author":[{"given":"Janis","family":"McFerrin","sequence":"first","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences, Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road Portland Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Patton","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences, Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road Portland Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Sunderhaus","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences, Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road Portland Oregon 97239"},{"name":"Molecular and Medical Genetics Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road Portland Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-2377","authenticated-orcid":false,"given":"Doris","family":"Kretzschmar","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences, Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road Portland Oregon 97239"},{"name":"Molecular and Medical Genetics Oregon Health &amp; Science University 3181 SW Sam Jackson Park Road Portland Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3200\/AEOH.58.8.484-497"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401030101"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079395"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00561.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20386"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.065490"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20753"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.07.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7516-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.022236"},{"key":"e_1_2_6_12_1","first-page":"745","article-title":"Comparative dose\u2010response studies of organophosphorus ester\u2010induced delayed neuropathy in rats and hens administered mipafox","volume":"13","author":"Dyer K. 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