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It is currently believed that different levels of MEK1\/ERK1\/2 activation define the state of SC differentiation. Thus, the identification of new regulators of MEK1\/ERK1\/2 signalling could help to decipher the context\u2010specific aspects driving the effects of this pathway on SC plasticity. In this perspective, we have investigated the potential role of KIAA1199, a protein that promotes ErbB and MEK1\/ERK1\/2 signalling in cancer cells, in SC plasticity. We depleted KIAA1199 in the SC\u2010derived MSC80 cell line with RNA\u2010interference\u2010based strategy and also generated Tamoxifen\u2010inducible and conditional mouse models in which <jats:italic>KIAA1199<\/jats:italic> is inactivated through homologous recombination, using the Cre\u2010lox technology. We show that the invalidation of KIAA1199 in SC decreases the expression of cJun and other negative regulators of myelination and elevates Krox20, driving them towards a pro\u2010myelinating phenotype. We further show that in dedifferentiation conditions, SC invalidated for KIAA1199 exhibit lower myelin clearance as well as increased myelination capacity. Finally, the Nrg1\u2010induced activation of the MEK\/ERK\/1\/2 pathway is severely reduced when KIAA1199 is absent, indicating that KIAA1199 promotes Nrg1\u2010dependent MEK1 and ERK1\/2 activation in SCs. In conclusion, this work identifies KIAA1199 as a novel regulator of MEK\/ERK\u2010induced SC dedifferentiation and contributes to a better understanding of the molecular control of SC dedifferentiation.<\/jats:p>","DOI":"10.1002\/glia.23188","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T06:48:39Z","timestamp":1499842119000},"page":"1682-1696","source":"Crossref","is-referenced-by-count":18,"title":["KIAA1199: A novel regulator of MEK\/ERK\u2010induced Schwann cell dedifferentiation"],"prefix":"10.1002","volume":"65","author":[{"given":"Ang\u00e9lique","family":"Boerboom","sequence":"first","affiliation":[{"name":"GIGA\u2010Neurosciences, University of Li\u00e8ge  Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Reusch","sequence":"additional","affiliation":[{"name":"GIGA\u2010Molecular Biology of Diseases University of Li\u00e8ge  Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Pieltain","sequence":"additional","affiliation":[{"name":"GIGA\u2010Neurosciences, University of Li\u00e8ge  Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Chariot","sequence":"additional","affiliation":[{"name":"GIGA\u2010Molecular Biology of Diseases University of Li\u00e8ge  Belgium"},{"name":"Walloon Excellence in Lifesciences and Biotechnology (WELBIO) Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-791X","authenticated-orcid":false,"given":"Rachelle","family":"Franzen","sequence":"additional","affiliation":[{"name":"GIGA\u2010Neurosciences, University of Li\u00e8ge  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