{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:21:54Z","timestamp":1790396514049,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["099222\/Z\/12\/Z"],"award-info":[{"award-number":["099222\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["100269\/Z\/12\/Z"],"award-info":[{"award-number":["100269\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["293544"],"award-info":[{"award-number":["293544"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L003236\/1"],"award-info":[{"award-number":["BB\/L003236\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We show that the G protein\u2010coupled receptor GPR37\u2010like 1 (GPR37L1) is expressed in most astrocytes and some oligodendrocyte precursors in the mouse central nervous system. This contrasts with GPR37, which is mainly in mature oligodendrocytes. Comparison of wild type and\n                    <jats:italic>\n                      Gpr37l1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice showed that loss of GPR37L1 did not affect the input resistance or resting potential of astrocytes or neurons in the hippocampus. However, GPR37L1\u2010mediated signalling inhibited astrocyte glutamate transporters and \u2013 surprisingly, given its lack of expression in neurons \u2013 reduced neuronal NMDA receptor (NMDAR) activity during prolonged activation of the receptors as occurs in ischemia. This effect on NMDAR signalling was not mediated by a change in the release of D\u2010serine or TNF\u2010\u03b1, two astrocyte\u2010derived agents known to modulate NMDAR function. After middle cerebral artery occlusion,\n                    <jats:italic>Gpr37l1<\/jats:italic>\n                    expression was increased around the lesion. Neuronal death was increased by \u223c40% in\n                    <jats:italic>\n                      Gpr37l1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    brain compared to wild type in an in vitro model of ischemia. Thus, GPR37L1 protects neurons during ischemia, presumably by modulating extracellular glutamate concentration and NMDAR activation.\n                  <\/jats:p>","DOI":"10.1002\/glia.23198","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T04:50:44Z","timestamp":1502340644000},"page":"47-61","source":"Crossref","is-referenced-by-count":57,"title":["G protein\u2010coupled receptor 37\u2010like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia"],"prefix":"10.1002","volume":"66","author":[{"given":"Sarah","family":"Jolly","sequence":"first","affiliation":[{"name":"Wolfson Institute for Biomedical Research, University College London London WC1E 6BT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Bazargani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Physiology and Pharmacology University College London London WC1E 6BT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra C.","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Wolfson Institute for Biomedical Research, University College London London WC1E 6BT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel P.","family":"Pringle","sequence":"additional","affiliation":[{"name":"Wolfson Institute for Biomedical Research, University College London London WC1E 6BT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Attwell","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Physiology and Pharmacology University College London London WC1E 6BT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7261-2485","authenticated-orcid":false,"given":"William D.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Wolfson Institute for Biomedical Research, University College London London WC1E 6BT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiliang","family":"Li","sequence":"additional","affiliation":[{"name":"Wolfson Institute for Biomedical Research, University College London London WC1E 6BT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013053"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22658"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4201"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.312"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2014.12.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aad1089"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200900447"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90088-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr130"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190928"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200205000-00008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7242"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1523\/JNEUROSCI.15-06-04417.1995","article-title":"Quantification of excitatory amino acid uptake at intact glutamatergic synapses by immunocytochemistry of exogenous d\u2010aspartate","volume":"15","author":"Gundersen V.","year":"1995","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01861.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08673"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199906)26:4<353::AID-GLIA9>3.0.CO;2-G"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771503767869980"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4778"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00407-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0859-x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04330.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/325529a0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3791\/53976"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.02.029"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00092-3"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200006050-00039"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314819110"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311766200"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.08.022"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219004110"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.01.076"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200111000-00005"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.029"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3836-12.2013"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/35002090"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)93869-Y"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2558"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5779-12.2013"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.4.1008"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04671"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2012.750430"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00170-7"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90865-S"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10884"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.1.168"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-14.2014"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.23198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.23198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:28:43Z","timestamp":1696390123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.23198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,10]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/glia.23198"],"URL":"https:\/\/doi.org\/10.1002\/glia.23198","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,10]]}}}