{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:07:36Z","timestamp":1791295656603,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["91712343"],"award-info":[{"award-number":["91712343"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008731","name":"European Leukodystrophy Association","doi-asserted-by":"publisher","award":["2014\u2010012L1"],"award-info":[{"award-number":["2014\u2010012L1"]}],"id":[{"id":"10.13039\/501100008731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"NWO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukodystrophies are often devastating diseases, presented with progressive clinical signs as spasticity, ataxia and cognitive decline, and lack proper treatment options. New therapy strategies for leukodystrophies mostly focus on oligodendrocyte replacement to rescue lack of myelin in the brain, even though disease pathology also often involves other glial cells and the spinal cord. In this study we investigated spinal cord pathology in a mouse model for Vanishing White Matter disease (VWM) and show that astrocytes in the white matter are severely affected. Astrocyte pathology starts postnatally in the sensory tracts, followed by changes in the astrocytic populations in the motor tracts. Studies in post\u2010mortem tissue of two VWM patients, a 13\u2010year\u2010old boy and a 6\u2010year\u2010old girl, confirmed astrocyte abnormalities in the spinal cord. For proper development of new treatment options for VWM and, possibly, other leukodystrophies, future studies should investigate spinal cord involvement.<\/jats:p>","DOI":"10.1002\/glia.23289","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T06:00:44Z","timestamp":1514527244000},"page":"862-873","source":"Crossref","is-referenced-by-count":22,"title":["<scp>A<\/scp>ffected astrocytes in the spinal cord of the leukodystrophy vanishing white matter"],"prefix":"10.1002","volume":"66","author":[{"given":"Prisca S.","family":"Leferink","sequence":"first","affiliation":[{"name":"Department of Pediatrics\/Child Neurology Amsterdam Neuroscience, VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Breeuwsma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Child Neurology Amsterdam Neuroscience, VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Bugiani","sequence":"additional","affiliation":[{"name":"Department of Pathology VU University Medical Center, Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo S.","family":"van der Knaap","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Child Neurology Amsterdam Neuroscience, VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Functional Genomics Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-3875","authenticated-orcid":false,"given":"Vivi M.","family":"Heine","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Child Neurology Amsterdam Neuroscience, VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Complex Trait Genetics Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Universiteit Amsterdam  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2017.01.001"},{"issue":"1","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"a020362","DOI":"10.1101\/cshperspect.a020362","article-title":"Astrocyte development and heterogeneity","volume":"7","author":"Bayraktar O. 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