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To date, it remains unclear how ribosomes localize to axons. They may be co\u2010transported with mRNAs or, as suggested by recent studies, transferred from Schwann cells (SC). Here, we generated transgenic \u201cRiboTracker\u201d mice expressing tdTomato\u2010tagged ribosomal protein L4 in specific cell types when crossed with Cre lines. Two neuronal RiboTracker\u2010Cre lines displayed extremely low levels of axonal L4\u2010tdTomato\u2010positive ribosomes. In contrast, two glial RiboTracker\u2010Cre lines revealed tagged ribosomes in sciatic nerve (SN) axons with increasing amounts after injury. Furthermore, non\u2010RiboTracker dorsal root ganglia co\u2010cultured with L4\u2010tdTomato\u2010expressing SCs displayed tagged ribosomes in axons. These data provide unequivocal evidence that SN axons receive ribosomes from SCs upon injury and indicate that glial cells are the main source of axonal ribosomes.<\/jats:p>","DOI":"10.1002\/glia.23327","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T18:02:22Z","timestamp":1522000942000},"page":"1591-1610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["<scp>A<\/scp> predominantly glial origin of axonal ribosomes after nerve injury"],"prefix":"10.1002","volume":"66","author":[{"given":"Kerstin","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Institute for Microanatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University Mainz Mainz 55131 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Schnatz","sequence":"additional","affiliation":[{"name":"Institute for Microanatomy and Neurobiology, 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