{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:40:35Z","timestamp":1790487635013,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2014RA4029"],"award-info":[{"award-number":["2014RA4029"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730035"],"award-info":[{"award-number":["81730035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571224"],"award-info":[{"award-number":["81571224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic pain is one of the most prevalent chronic diseases in the world. The plastic changes of sensory neurons in dorsal root ganglia (DRG) have been extensively studied as the underlying periphery mechanism. Recent studies revealed that satellite cells, the major glial cells in DRG, also played important roles in the development\/modulation of chronic pain. Whether DRG satellite glial cells generate new neurons as their counterparts in enteric nerve ganglia and carotid body do under pathological conditions remains poorly investigated. Here, we report that chronic pain induces proliferation and upregulation of progenitor markers in the sex\u2010determining region Y\u2010box 2 (Sox2)\u2010 and platelet\u2010derived growth factor receptor alpha (PDGFR\u03b1)\u2010positive satellite glial cells. BrdU incorporation assay revealed the generation of IB4\u2010 and CGRP\u2010positive neurons, but not NF200\u2010positive neurons in DRG ipsilateral to injury. Genetic fate tracings showed that PDGFR\u03b1\u2010positive cells did not generate neurons, whereas Sox2\u2010positive cells produced both IB4\u2010 and CGRP\u2010positive neurons. Interestingly, glial fibrillary acidic protein\u2010positive cells, a subpopulation of Sox2\u2010positive satellites, only gave birth to IB4\u2010positive neurons. Local persistent delivery of tetrodotoxin to the sciatic nerve trunk significantly reduced the pain\u2010induced neurogenesis. Furthermore, patch\u2010clamp studies demonstrated that these glia\u2010derived new neurons could fire action potentials and respond to capsaicin. Taken together, our data demonstrated a chronic pain\u2010induced nociceptive neurogenesis in DRG from Sox2\u2010positive satellite cells, indicating a possible contribution of DRG neurogenesis to the pathology of chronic pain.<\/jats:p>","DOI":"10.1002\/glia.23588","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T08:06:36Z","timestamp":1547625996000},"page":"1062-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Chronic pain induces nociceptive neurogenesis in dorsal root ganglia from Sox2\u2010positive satellite cells"],"prefix":"10.1002","volume":"67","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Institute of Neurosciences, School of Basic Medicine Fourth Military Medical University  Xi'an Shaanxi China"},{"name":"Department of Anatomy, Institute of Basic Medical Science Xi'an Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rougang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Institute of Neurosciences, School of Basic Medicine Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Institute of Neurosciences, School of Basic Medicine Fourth Military Medical University  Xi'an Shaanxi China"},{"name":"Department of Anatomy, Institute of Basic Medical Science Xi'an Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Institute of Neurosciences, School of Basic Medicine Fourth Military Medical University  Xi'an Shaanxi 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