{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:05:29Z","timestamp":1792145129050,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004628","name":"MedImmune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heterogeneity is a widely recognized phenomenon within the majority of cell types in the body including cells of the central nervous system (CNS). The heterogeneity of neurons based on their distinct transmission modes and firing patterns has been recognized for decades, and is necessary to coordinate the immense variety of functions of the CNS. More recently, heterogeneity in glial cells has been identified, including heterogeneity in oligodendrocyte progenitor cells (OPCs) and oligodendrocytes. OPC subpopulations have been described based on their developmental origin, anatomical location in the grey or white matter, and expression of surface receptors. Oligodendrocytes are categorised according to differences in gene expression, myelinogenic potential, and axon specificity. Much of what is described as heterogeneity in oligodendrocyte lineage cells (OLCs) is based on phenotypic differences. However, without evidence for functional differences between putative subgroups of OLCs, distinguishing heterogeneity from plasticity and lineage state is difficult. Identifying functional differences between phenotypically distinct groups are therefore necessary for a deeper understanding of the role of OLCs in health and disease.<\/jats:p>","DOI":"10.1002\/glia.23607","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T03:17:38Z","timestamp":1554866258000},"page":"1797-1805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-0621","authenticated-orcid":false,"given":"Sarah","family":"Foerster","sequence":"first","affiliation":[{"name":"Wellcome Trust\u2010Medical Research Council Cambridge Stem Cell Institute, Clifford Allbutt Building, Cambridge Biomedical Campus University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myfanwy F. E.","family":"Hill","sequence":"additional","affiliation":[{"name":"Wellcome Trust\u2010Medical Research Council Cambridge Stem Cell Institute, Clifford Allbutt Building, Cambridge Biomedical Campus University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6522-2104","authenticated-orcid":false,"given":"Robin J. M.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Wellcome Trust\u2010Medical Research Council Cambridge Stem Cell Institute, Clifford Allbutt Building, Cambridge Biomedical Campus University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.07.056"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4178-07.2008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.028"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00871"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2410"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.074252"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113540109"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0928-12.2012"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23305"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.069"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00210-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6000-09.2010"},{"key":"e_1_2_11_14_1","first-page":"5","article-title":"Tercera aportaci\u00f3n al conocimiento morfol\u00f3gico e interpretaci\u00f3n funcional de la oligodendrogl\u00eda","author":"R\u00edo Hortega P.","year":"1928","journal-title":"Memorias De La Real Sociedad Espa\u00f1ola De Historia Natural"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2831-08.2008"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01777"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.136"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252304"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2001-12.2013"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.009"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn2060"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20440"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1620"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00237.1998"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1934-10.2010"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.043"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511001103"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(84)90064-X"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1220845"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.07.005"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6463"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3991"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.05.011"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0849-14.2015"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21339"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23076"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb01388.x"},{"issue":"2","key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1242\/dev.115.2.535","article-title":"PDGF receptors in the rat CNS: During late neurogenesis, PDGF alpha\u2010receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage","volume":"115","author":"Pringle N. P.","year":"1992","journal-title":"Development (Cambridge, England)"},{"issue":"2","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dev.117.2.525","article-title":"A singularity of PDGF alpha\u2010receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage","volume":"117","author":"Pringle N. P.","year":"1993","journal-title":"Development (Cambridge, England)"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X09990354"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/303390a0"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2220"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.05.016"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36428"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21156"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490370106"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90477-2"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.12.020"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-09-02737.1987"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.5.2521"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.3.1510"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249766"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6474-10.2011"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222381"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.026"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3503"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22929"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07082.x"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4351"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.006"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.04.002"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80898-3"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21203"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.23607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.23607","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.23607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T12:14:52Z","timestamp":1694261692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.23607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/glia.23607"],"URL":"https:\/\/doi.org\/10.1002\/glia.23607","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735522114.793563737","asserted-by":"object"}]},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,10]]},"assertion":[{"value":"2018-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}