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Astrocytes are gap junction\u2010coupled not only to neighboring astrocytes, but also to oligodendrocytes, forming so\u2010called panglial syncytia. It is not known, however, whether glial cells in panglial syncytia transmit information using Ca<jats:sup>2+<\/jats:sup> signaling. We used confocal Ca<jats:sup>2+<\/jats:sup> imaging to study intercellular communication between astrocytes and olfactory ensheathing glial cells (OECs) in in\u2010toto preparations of the mouse olfactory bulb. Our results demonstrate that Ca<jats:sup>2+<\/jats:sup> transients in juxtaglomerular astrocytes, evoked by local photolysis of \u201ccaged\u201d ATP and \u201ccaged\u201d <jats:italic>t<\/jats:italic>ACPD, led to subsequent Ca<jats:sup>2+<\/jats:sup> responses in OECs. This transmission of Ca<jats:sup>2+<\/jats:sup> responses from astrocytes to OECs persisted in the presence of neuronal inhibition, but was absent when gap junctional coupling was suppressed with carbenoxolone. When Ca<jats:sup>2+<\/jats:sup> transients were directly evoked in OECs by puff application of DHPG, they resulted in delayed Ca<jats:sup>2+<\/jats:sup> responses in juxtaglomerular astrocytes, indicating that panglial transmission of Ca<jats:sup>2+<\/jats:sup> signals occurred in a bidirectional manner. In addition, panglial transmission of Ca<jats:sup>2+<\/jats:sup> signals from astrocytes to OECs resulted in vasoconstriction of OEC\u2010associated blood vessels in the olfactory nerve layer. Our results demonstrate functional transmission of Ca<jats:sup>2+<\/jats:sup> signals between different classes of glial cells within gap junction\u2010coupled panglial networks and the resulting regulation of blood vessel diameter in the olfactory bulb.<\/jats:p>","DOI":"10.1002\/glia.23613","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T23:26:35Z","timestamp":1552951595000},"page":"1385-1400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca<sup>2+<\/sup> transients and neurovascular coupling"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0976-005X","authenticated-orcid":false,"given":"Antonia","family":"Beiersdorfer","sequence":"first","affiliation":[{"name":"Division of Neurophysiology University of Hamburg  Hamburg 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