{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:47:32Z","timestamp":1790318852572,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mild\u2010traumatic brain injury (mTBI) represents ~80% of all emergency room visits and increases the probability of developing long\u2010term cognitive disorders in children. To date, molecular and cellular mechanisms underlying post\u2010mTBI cognitive dysfunction are unknown. Astrogliosis has been shown to significantly alter astrocytes' properties following brain injury, potentially leading to significant brain dysfunction. However, such alterations have never been investigated in the context of juvenile mTBI (jmTBI). A closed\u2010head injury model was used to study jmTBI on postnatal\u2010day 17 mice. Astrogliosis was evaluated using glial fibrillary acidic protein (GFAP), vimentin, and nestin immunolabeling in somatosensory cortex (SSC), dentate gyrus (DG), amygdala (AMY), and infralimbic area (ILA) of prefrontal cortex in both hemispheres from 1 to 30\u2009days postinjury (dpi). In vivo T2\u2010weighted\u2010imaging (T2WI) and diffusion tensor imaging (DTI) were performed at 7 and 30\u2009dpi to examine tissue level structural alterations. Increased GFAP\u2010labeling was observed up to 30\u2009dpi in the ipsilateral SSC, the initial site of the impact. However, vimentin and nestin expression was not perturbed by jmTBI. The morphology of GFAP positive cells was significantly altered in the SSC, DG, AMY, and ILA up to 7\u2009dpi that some correlated with magnetic resonance imaging changes. T2WI and DTI values were significantly altered at 30\u2009dpi within these brain regions most prominently in regions distant from the impact site. Our data show that jmTBI triggers changes in astrocytic phenotype with a distinct spatiotemporal pattern. We speculate that the presence and time course of astrogliosis may contribute to pathophysiological processes and long\u2010term structural alterations following jmTBI.<\/jats:p>","DOI":"10.1002\/glia.23736","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T13:19:49Z","timestamp":1572527989000},"page":"528-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses"],"prefix":"10.1002","volume":"68","author":[{"given":"Tifenn","family":"Cl\u00e9ment","sequence":"first","affiliation":[{"name":"CNRS UMR5287 University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong B.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, Basic Sciences Loma Linda University School of Medicine  Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Ichkova","sequence":"additional","affiliation":[{"name":"CNRS UMR5287 University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Rodriguez\u2010Grande","sequence":"additional","affiliation":[{"name":"CNRS UMR5287 University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Line","family":"Fournier","sequence":"additional","affiliation":[{"name":"CNRS UMR5287 University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Aussudre","sequence":"additional","affiliation":[{"name":"CNRS UMR5287 University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ogier","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Neurosciences et Sciences Cognitives, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  Br\u00e9tigny\u2010sur\u2010Orge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  Irvine Irvine, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Canini","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Neurosciences et Sciences Cognitives, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  Br\u00e9tigny\u2010sur\u2010Orge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Koehl","sequence":"additional","affiliation":[{"name":"Neurocentre Magendie INSERM U1215  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djoher Nora","family":"Abrous","sequence":"additional","affiliation":[{"name":"Neurocentre Magendie INSERM U1215  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-6950","authenticated-orcid":false,"given":"Andre","family":"Obenaus","sequence":"additional","affiliation":[{"name":"Department of Physiology, Basic Sciences Loma Linda University School of Medicine  Loma Linda California"},{"name":"Department of Pediatrics University of California  Irvine Irvine, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-0519","authenticated-orcid":false,"given":"Jerome","family":"Badaut","sequence":"additional","affiliation":[{"name":"CNRS UMR5287 University of Bordeaux  Bordeaux France"},{"name":"Department of Physiology, Basic Sciences Loma Linda University School of Medicine  Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20829"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617711000907"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3371"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.04.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-013-9237-2"},{"key":"e_1_2_10_9_1","first-page":"271678x18806893","article-title":"Involvement of caveolin\u20101 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis","author":"Blochet C.","year":"2018","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101669"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr161"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.03.020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.034"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2403"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15061171"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2011.2126587"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4806-13.2014"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199410000-00011"},{"key":"e_1_2_10_19_1","first-page":"7","article-title":"Long\u2010term effects of mild traumatic brain injury on cognitive performance","author":"Dean P. J. A.","year":"2013","journal-title":"Frontiers in Human Neuroscience"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2010-0529"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23582"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0164-17.2017"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4407"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045-9912.196900"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.07.006"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-017-2225-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10013"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-017-3474-2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13581-z"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20207"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(07)82005-8"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000472"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp184"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.06.025"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.11.017"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23336"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2588"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.04.001"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3816-2_18"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32834cd523"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020420"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-199912000-00009"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5294"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.008"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2121-13.2013"},{"key":"e_1_2_10_50_1","article-title":"Corpus callosum vasculature predicts white matter microstructure abnormalities after pediatric mild traumatic brain injury","author":"Wendel K. M.","year":"2018","journal-title":"Journal of Neurotrauma"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30279-X"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.055"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28713"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6221-11.2012"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.23736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.23736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.23736","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.23736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T21:08:58Z","timestamp":1694120938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.23736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,31]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/glia.23736"],"URL":"https:\/\/doi.org\/10.1002\/glia.23736","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,31]]},"assertion":[{"value":"2018-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}