{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:56:06Z","timestamp":1790607366925,"version":"4.1.0"},"reference-count":126,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007263","name":"Virginia Polytechnic Institute and State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS105141"],"award-info":[{"award-number":["NS105141"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI124677"],"award-info":[{"award-number":["AI124677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Infection and inflammation within the brain induces changes in neuronal connectivity and function. The intracellular protozoan parasite,\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    , is one pathogen that infects the brain and can cause encephalitis and seizures. Persistent infection by this parasite is also associated with behavioral alterations and an increased risk for developing psychiatric illness, including schizophrenia. Current evidence from studies in humans and mouse models suggest that both seizures and schizophrenia result from a loss or dysfunction of inhibitory synapses. In line with this, we recently reported that persistent\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection alters the distribution of glutamic acid decarboxylase 67 (GAD67), an enzyme that catalyzes GABA synthesis in inhibitory synapses. These changes could reflect a redistribution of presynaptic machinery in inhibitory neurons or a loss of inhibitory nerve terminals. To directly assess the latter possibility, we employed serial block face scanning electron microscopy (SBFSEM) and quantified inhibitory perisomatic synapses in neocortex and hippocampus following parasitic infection. Not only did persistent infection lead to a significant loss of perisomatic synapses, it induced the ensheathment of neuronal somata by myeloid\u2010derived cells. Immunohistochemical, genetic, and ultrastructural analyses revealed that these myeloid\u2010derived cells included activated microglia. Finally, ultrastructural analysis identified myeloid\u2010derived cells enveloping perisomatic nerve terminals, suggesting they may actively displace or phagocytose synaptic elements. Thus, these results suggest that activated microglia contribute to perisomatic inhibitory synapse loss following parasitic infection and offer a novel mechanism as to how persistent\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection may contribute to both seizures and psychiatric illness.\n                  <\/jats:p>","DOI":"10.1002\/glia.23816","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T04:34:14Z","timestamp":1583901254000},"page":"1968-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["<i>Toxoplasma<\/i>\n                    infection induces microglia\u2010neuron contact and the loss of perisomatic inhibitory synapses"],"prefix":"10.1002","volume":"68","author":[{"given":"Gabriela L.","family":"Carrillo","sequence":"first","affiliation":[{"name":"Center for Neurobiology Research Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"Graduate Program in Translational Biology, Medicine, and Health Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"Ballard","sequence":"additional","affiliation":[{"name":"Center for Neurobiology Research Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"Roanoke Valley Governor's School  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Glausen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zack","family":"Boone","sequence":"additional","affiliation":[{"name":"Center for Neurobiology Research Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"School of Neuroscience Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Teamer","sequence":"additional","affiliation":[{"name":"Center for Neurobiology Research Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"FBRI neuroSURF Program  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus L.","family":"Hinkson","sequence":"additional","affiliation":[{"name":"Center for Neurobiology Research Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"Virginia Tech Carilion School of Medicine  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Wohlfert","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira J.","family":"Blader","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-7782","authenticated-orcid":false,"given":"Michael A.","family":"Fox","sequence":"additional","affiliation":[{"name":"Center for Neurobiology Research Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"School of Neuroscience Virginia Tech  Blacksburg Virginia USA"},{"name":"Department of Biological Sciences Virginia Tech  Blacksburg Virginia USA"},{"name":"Department of Pediatrics Virginia Tech Carilion School of Medicine  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00789-18"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900141106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192233099"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028925"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2447"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2000.1182"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.11.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00073"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22821"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.125"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00325030"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.019"},{"key":"e_1_2_8_14_1","first-page":"47","article-title":"The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: Old fashioned, but still in vogue","volume":"5","author":"Brisch R.","year":"2014","journal-title":"Frontiers in Psychiatry"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01428-15"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.01.026"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0057-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150444"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005447"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5486"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220272110"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0666"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005643"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01042-10"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020329"},{"issue":"458","key":"e_1_2_8_27_1","first-page":"e419","article-title":"Neurons under T cell attack coordinate phagocyte\u2010mediated synaptic stripping","volume":"175","author":"Di Liberto G.","year":"2018","journal-title":"Cell"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61013-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000772"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt113"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.11.011"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12866"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-016-9822-1"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091032"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.02.008"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.035"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03834.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004801"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2012.10.005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/723184"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-010-0124-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs010"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00249"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687883"},{"issue":"153","key":"e_1_2_8_46_1","first-page":"e158","article-title":"Altered cortical ensembles in mouse models of schizophrenia","volume":"94","author":"Hamm J. P.","year":"2017","journal-title":"Neuron"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-9-16"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.08.003"},{"key":"e_1_2_8_49_1","article-title":"Complement\u2010dependent synapse loss and microgliosis in a mouse model of multiple sclerosis","author":"Hammond J. W.","year":"2019","journal-title":"BioRxiv"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035516"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1787"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8373"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20587"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00217-16"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2016.04.012"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0217-z"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.2.416"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.6.476"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00685-4"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.12.023"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102072"},{"issue":"566","key":"e_1_2_8_62_1","first-page":"e569","article-title":"The TREM2\u2010APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann S.","year":"2017","journal-title":"Immunity"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122143"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2376"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12485"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00735.x"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1242-1"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.05.013"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00139-19"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3155"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-07-04906.1995"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.08.005"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.074153"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.009928"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33498"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"issue":"1387","key":"e_1_2_8_77_1","first-page":"e1314","article-title":"Long\u2010lasting rescue of network and cognitive dysfunction in a genetic schizophrenia model","volume":"178","author":"Mukherjee A.","year":"2019","journal-title":"Cell"},{"key":"e_1_2_8_78_1","first-page":"e54214","article-title":"Analysis of brain mitochondria using serial block\u2010face scanning electron microscopy","author":"Mukherjee K.","year":"2016","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4882fje"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003525"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2007.05.010"},{"issue":"297","key":"e_1_2_8_82_1","first-page":"e296","article-title":"TDP\u201043 depletion in microglia promotes amyloid clearance but also induces synapse loss","volume":"95","author":"Paolicelli R. C.","year":"2017","journal-title":"Neuron"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.04.003"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.014183"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12157"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3950"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20100024"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1123"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3446"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12676"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.12.020"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023866"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132528"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00803"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.026"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2003.12.006"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16549"},{"key":"e_1_2_8_98_1","first-page":"223","article-title":"The role of GABAergic system in neurodevelopmental disorders: A focus on autism and epilepsy","volume":"3","author":"Sgado P.","year":"2011","journal-title":"International Journal of Physiology, Pathophysiology and Pharmacology"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24016"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00890.x"},{"key":"e_1_2_8_101_1","first-page":"317","article-title":"An electron microscope and immunohistochemical study of the intracellular location of Toxoplasma tissue cysts within the brains of mice with congenital toxoplasmosis","volume":"70","author":"Sims T. A.","year":"1989","journal-title":"British Journal of Experimental Pathology"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090372"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006000886"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.036"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10926-6"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.11.004"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201509085"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22228"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421844112"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1086-8"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20462"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000527"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.033"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1685-07.2007"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18283"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608310104"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210888"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.12.019"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02465-14"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006272"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03566-5"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.04.001"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.19"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00700"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.04.009"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby082"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132477"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.23816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.23816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.23816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.23816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:45:57Z","timestamp":1693892757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.23816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,11]]},"references-count":126,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/glia.23816"],"URL":"https:\/\/doi.org\/10.1002\/glia.23816","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737536741.793588178","asserted-by":"object"}]},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,11]]},"assertion":[{"value":"2019-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}