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PAR1 knockout mice show improved outcomes after experimental spinal cord injury (SCI), however information regarding the underpinning cellular and molecular mechanisms is lacking. Here we demonstrate that genetic blockade of PAR1 in female mice results in improvements in sensorimotor co\u2010ordination after thoracic spinal cord lateral compression injury. We document improved neuron preservation with increases in Synapsin\u20101 presynaptic proteins and GAP43, a growth cone marker, after a 30\u2009days recovery period. These improvements were coupled to signs of enhanced myelin resiliency and repair, including increases in the number of mature oligodendrocytes, their progenitors and the abundance of myelin basic protein. These significant increases in substrates for neural recovery were accompanied by reduced astrocyte (Serp1) and microglial\/monocyte (CD68 and iNOS) pro\u2010inflammatory markers, with coordinate increases in astrocyte (S100A10 and Emp1) and microglial (Arg1) markers reflective of pro\u2010repair activities. Complementary astrocyte\u2010neuron co\u2010culture bioassays suggest astrocytes with PAR1 loss\u2010of\u2010function promote both neuron survival and neurite outgrowth. Additionally, the pro\u2010neurite outgrowth effects of switching off astrocyte PAR1 were blocked by inhibiting TrkB, the high affinity receptor for brain derived neurotrophic factor. Altogether, these studies demonstrate unique modulatory roles for PAR1 in regulating glial\u2010neuron interactions, including the capacity for neurotrophic factor signaling, and underscore its position at neurobiological intersections critical for the response of the CNS to injury and the capacity for regenerative repair and restoration of function.<\/jats:p>","DOI":"10.1002\/glia.24012","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T22:26:06Z","timestamp":1619130366000},"page":"2111-2132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The thrombin receptor modulates astroglia\u2010neuron trophic coupling and neural repair after spinal cord injury"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-4727","authenticated-orcid":false,"given":"Ha Neui","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physical 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