{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:05:30Z","timestamp":1791464730636,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015279","name":"Osaka Foundation for Promotion of Fundamental Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Single oligodendrocytes produce myelin sheaths around multiple axons in the central nervous system. Interfascicular oligodendrocytes (IOs) facilitate nerve conduction, but their detailed morphologies remain largely unknown. In the present study, we three\u2010dimensionally reconstructed IOs in the corpus callosum of adult mouse using serial block face scanning electron microscopy. The cell bodies of IOs were morphologically polarized and extended thick processes from the cytoplasm\u2010rich part of the cell. Processes originating from the cell body of each IO can be classified into two types: one myelinates an axon without branching, while the other type branches and each branch myelinates a distinct axon. Myelin sheaths originating from a particular IO have biased thicknesses, wrapping axons of a limited range of diameters. Consistent with this finding, IOs transduced and visualized with a rabies viral vector expressing GFP showed statistically significant variation in their myelination patterns. We further reconstructed the sheath immediately adjacent to that derived from each of the analyzed IOs; the thicknesses of the pair of sheaths were significantly correlated despite emanating from different IOs. These results suggest that a single axon could regulate myelin sheath thicknesses, even if the sheaths are derived from distinct IOs. Collectively, our results indicate that the IOs have their own myelin profiles defined by myelin thickness and axonal diameter although axons may regulate thickness of myelin sheath.<\/jats:p>","DOI":"10.1002\/glia.24055","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T11:00:07Z","timestamp":1624532407000},"page":"2488-2502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Large\u2010scale electron microscopic volume imaging of interfascicular oligodendrocytes in the mouse corpus callosum"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-9093","authenticated-orcid":false,"given":"Tatsuhide","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neuroscience Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Division of Histology and Cell Biology Jichi Medical University, School of Medicine  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Osanai","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Division of Histology and Cell Biology Jichi Medical University, School of Medicine  Shimotsuke Japan"},{"name":"Division of Neurobiology and Bioinformatics National Institute for Physiological Sciences  Okazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Section of Electron Microscopy, Supportive Center for Brain Research National Institute for Physiological Sciences  Okazaki Japan"},{"name":"Department of Anatomy II and Cell Biology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truc Quynh","family":"Thai","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Division of Histology and Cell Biology Jichi Medical University, School of Medicine  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neuroscience Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeaki","family":"Shinjo","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neuroscience Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neuroscience Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouko","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neuroscience Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Wanaka","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neuroscience Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.08.062"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.871"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.10.022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01184071"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00734520"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4200"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.05.013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.2.384"},{"key":"e_1_2_9_10_1","first-page":"E11807\u2010E11816","article-title":"The adult oligodendrocyte can participate in remyelination","volume":"115","author":"Duncan I. 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