{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:43:09Z","timestamp":1790779389327,"version":"4.1.0"},"reference-count":201,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL146574"],"award-info":[{"award-number":["R01HL146574"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG064422"],"award-info":[{"award-number":["R21AG064422"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG073862"],"award-info":[{"award-number":["R21AG073862"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG065345"],"award-info":[{"award-number":["RF1AG065345"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Oligodendrocytes are the cells that myelinate axons and provide trophic support to neurons in the CNS. Their dysfunction has been associated with a group of disorders known as demyelinating diseases, such as multiple sclerosis. Oligodendrocytes are derived from oligodendrocyte precursor cells, which differentiate into premyelinating oligodendrocytes and eventually mature oligodendrocytes. The development and function of oligodendrocytes are tightly regulated by a variety of molecules, including laminin, a major protein of the extracellular matrix. Accumulating evidence suggests that laminin actively regulates every aspect of oligodendrocyte biology, including survival, migration, proliferation, differentiation, and myelination. How can laminin exert such diverse functions in oligodendrocytes? It is speculated that the distinct laminin isoforms, laminin receptors, and\/or key signaling molecules expressed in oligodendrocytes at different developmental stages are the reasons. Understanding molecular targets and signaling pathways unique to each aspect of oligodendrocyte biology will enable more accurate manipulation of oligodendrocyte development and function, which may have implications in the therapies of demyelinating diseases. Here in this review, we first introduce oligodendrocyte biology, followed by the expression of laminin and laminin receptors in oligodendrocytes and other CNS cells. Next, the functions of laminin in oligodendrocyte biology, including survival, migration, proliferation, differentiation, and myelination, are discussed in detail. Last, key questions and challenges in the field are discussed. By providing a comprehensive review on laminin's roles in OL lineage cells, we hope to stimulate novel hypotheses and encourage new research in the field.<\/jats:p>","DOI":"10.1002\/glia.24117","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T02:43:08Z","timestamp":1636771388000},"page":"414-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Laminin regulates oligodendrocyte development and myelination"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0053-2288","authenticated-orcid":false,"given":"Minkyung","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology, Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8020-9696","authenticated-orcid":false,"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology, Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.167908"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199909000-00012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.02.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051342"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490270319"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-04-01302.2001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","unstructured":"Back S. A. Luo N. L. Borenstein N. S. Volpe J. J. &Kinney H. C.(2002).Arrested Oligodendrocyte lineage progression during human cerebral White matter development: Dissociation between the timing of progenitor differentiation and Myelinogenesis 61(2) 197\u2013211.https:\/\/doi.org\/10.1093\/jnen\/61.2.197","DOI":"10.1093\/jnen\/61.2.197"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20954"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220104110"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10967.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20519"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.04.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007097226688"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(02)01437-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10627"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/367371a0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.038679"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0444-06.2006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6094-7"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.15-08-05502.1995"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.05.009"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb10930.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001625"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0781"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(00)80469-9"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200807010"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.016378"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.12.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201212032"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1156-14.2014"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200304154"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0928-12.2012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","unstructured":"Coles E. G. Gammill L. S. Miner J. H. &Bronner\u2010Fraser M.(2006).Abnormalities in neural crest cell migration in laminin \u03b15 mutant mice 289(1) 218\u2013228.https:\/\/doi.org\/10.1016\/j.ydbio.2005.10.031","DOI":"10.1016\/j.ydbio.2005.10.031"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb865"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02819"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200404076"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20966"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1116"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0041"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.084"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5725-03.2004"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000232525.65682.a2"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694756"},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","unstructured":"Duncan I. D. Hammang J. P. &Trapp B. D.(1987).Abnormal compact myelin in the myelin\u2010deficient rat: Absence of proteolipid protein correlates with a defect in the intraperiod line 84(17) 6287\u20136291.https:\/\/doi.org\/10.1073\/pnas.84.17.6287","DOI":"10.1073\/pnas.84.17.6287"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20001101)62:3<336::Aid-jnr3>3.0.Co;2-h"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190927"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","unstructured":"Eugen\u00edn\u2010Von Bernhardi J. &Dimou L.(2016).NG2\u2010glia more than progenitor cells. In (pp. 27\u201045): Springer international publishing.","DOI":"10.1007\/978-3-319-40764-7_2"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07600.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22839"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20462"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1255"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9764"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111416"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(99)80506-5"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.3.457"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010155200"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11007"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22484"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-019-00709-8"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-019-0688-5"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36450"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20406"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.05.021"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.087817"},{"issue":"5","key":"e_1_2_9_67_1","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1046\/j.1471-4159.1999.01913.x","article-title":"Myelin\u2010associated oligodendrocytic basic protein mRNAs reside at different subcellular locations","volume":"73","author":"Gould R. M.","year":"1999","journal-title":"Journal of Neurochemistry"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5369.1610"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1360-10.2010"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17749689"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1944-11.2011"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.160"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002010203"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.098418"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2007.01130.x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22111"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3390"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030775"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00496-3"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.05.022"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.120.028928"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.009"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.009"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1620"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1996.0024"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.5.869"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084292"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.14.2989"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn096"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2002.1124"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06926.x"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3550"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20343"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11314"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00443-07"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13241"},{"key":"e_1_2_9_97_1","doi-asserted-by":"crossref","unstructured":"Li Z. He Y. Fan S. &Sun B.(2015).Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination 31(5) 617\u2013625.https:\/\/doi.org\/10.1007\/s12264-015-1555-3","DOI":"10.1007\/s12264-015-1555-3"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.212076"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpsc.17"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00027"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/769412"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90215-2"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.18-14-05354.1998"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3678-13.2014"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.07.012"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-22-07240.1996"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.23.4271"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.486134"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600585"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1003"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.11.029"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1482-08.2008"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09614"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09614"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013101"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0676-8"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12454"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(98)00118-8"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-016-0242-2"},{"issue":"1","key":"e_1_2_9_120_1","first-page":"37","article-title":"Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia","volume":"149","author":"Okada Y.","year":"1996","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/ahe.12348"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-15-12"},{"issue":"1","key":"e_1_2_9_123_1","first-page":"154","article-title":"Characterization of integrin receptors in normal and neoplastic human brain","volume":"143","author":"Paulus W.","year":"1993","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-3806(96)00124-1"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22004"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci90610"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.12.009"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1740925x04000109"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03472.x"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X09990354"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.14.2723"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04319.x"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22365"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0888-09.2009"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(01)00292-5"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.197848"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2220"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22099"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09611"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01273"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508101943"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.172148"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199708)20:4<284::AID-GLIA2>3.0.CO;2-6"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0819"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(89)90014-3"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.108.172015"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21156"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020479"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.08.003"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.5.933"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.044"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.151043"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21228"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8668"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.24.4993"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2018"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.215802"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-222364"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.044"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3153"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10114"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56488-7"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14207-0"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2015.01.015"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.120.1.261"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490390411"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23735"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01568.x"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.04.026"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.92.3.877"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0359-y"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328x(88)90006-x"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3839"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.01.027"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.08.005"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23256"},{"key":"e_1_2_9_177_1","doi-asserted-by":"crossref","unstructured":"Van'T Veer A. Du Y. Fischer T. Z. Boetig D. R. Wood M. R. &Dreyfus C. F.(2009).Brain\u2010derived neurotrophic factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway 87(1) 69\u201378.https:\/\/doi.org\/10.1002\/jnr.21841","DOI":"10.1002\/jnr.21841"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25739"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.8.2529"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.28.4.858"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(01)00237-9"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20006"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00284"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.04.014"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1957"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3034-04.2005"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10323"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.11.028"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2381-0"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678x18801467"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4413"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2019.10.001"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201607099"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.006"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.22680"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00827"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1860-14.2014"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1510-18.2018"},{"key":"#cr-split#-e_1_2_9_200_1.1","doi-asserted-by":"crossref","unstructured":"Zhu B. Nicholls M. Gu Y. Zhang G. Zhao C. Franklin R. &Song B.(2016).Electric signals regulate the directional migration of Oligodendrocyte progenitor cells (OPCs) via \u03b21 integrin 17","DOI":"10.3390\/ijms17111948"},{"key":"#cr-split#-e_1_2_9_200_1.2","doi-asserted-by":"crossref","unstructured":"(11) 1948.https:\/\/doi.org\/10.3390\/ijms17111948","DOI":"10.3390\/ijms17111948"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.004895"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.24117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.24117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.24117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T10:47:38Z","timestamp":1699786058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.24117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,12]]},"references-count":201,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/glia.24117"],"URL":"https:\/\/doi.org\/10.1002\/glia.24117","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,12]]},"assertion":[{"value":"2021-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}