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Despite its rich expression in oligodendrocyte (OL) lineage cells and an emerging link with demyelinating disease, the function of K\n                    <jats:sub>ir<\/jats:sub>\n                    4.1 in OLs is unclear. Here we show a novel role of K\n                    <jats:sub>ir<\/jats:sub>\n                    4.1 in OL development. K\n                    <jats:sub>ir<\/jats:sub>\n                    4.1 expression is markedly greater in OLs than in OL precursor cells (OPCs), and the down\u2010regulation of K\n                    <jats:sub>ir<\/jats:sub>\n                    4.1 impairs OL maturation by affecting OPC differentiation. Interestingly, K\n                    <jats:sub>ir<\/jats:sub>\n                    4.1 regulates the intracellular pH of OPCs and OLs via the Na\n                    <jats:sup>+<\/jats:sup>\n                    \/H\n                    <jats:sup>+<\/jats:sup>\n                    exchanger, which underlies impeded OPC differentiation by K\n                    <jats:sub>ir<\/jats:sub>\n                    4.1 inhibition. Furthermore, K\n                    <jats:sub>ir<\/jats:sub>\n                    4.1 regulates GSK3\u03b2 and SOX10, two molecules critical to OPC development. Collectively, our work opens a new avenue to understanding the functions of K\n                    <jats:sub>ir<\/jats:sub>\n                    4.1 and intracellular pH in OLs.\n                  <\/jats:p>","DOI":"10.1002\/glia.24240","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T09:49:48Z","timestamp":1656668988000},"page":"2093-2107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Potassium channel K\n                    <sub>ir<\/sub>\n                    4.1 regulates oligodendrocyte differentiation via intracellular\n                    <scp>pH<\/scp>\n                    regulation"],"prefix":"10.1002","volume":"70","author":[{"given":"Na","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Physiology and Department of Neurology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Neurology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University School of Medicine  Hangzhou China"},{"name":"Key Laboratory of Brain Science, Guizhou Institution of Higher Education Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong\u2010Yu","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Neurology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Tai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Neurology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cranial Cerebral Diseases, Department of Neurobiology of Basic Medical College Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cranial Cerebral Diseases, Department of Neurobiology of Basic Medical College Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Lan","family":"Hu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cranial Cerebral Diseases, Department of Neurobiology of Basic Medical College Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengsheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences Hangzhou Normal University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-5328","authenticated-orcid":false,"given":"Ying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Neurology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11298"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810276"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(20000315)59:6<731::AID-JNR5>3.0.CO;2-G"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2004.02.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2764-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201302131"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143854"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.05.035"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25752"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0723-07.2007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2480"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200804161"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1668"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356661"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041440310"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20574"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2990-06.2006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05715.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb17768.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0021-8782.2004.00288.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017373"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000097"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14216.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34829"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.168"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4071"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113034"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1961-12.2013"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6463"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1139\/y92-275"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.3.R581"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05429.2001"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-08-03333.1993"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101319200"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1110-3"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.105"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199412300-00049"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-017-2242-8"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098\u20101136(200006)30:4<362::aid\u2010glia50>3.0.co;2\u20104"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403099200"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901749106"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-050511-102349"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3790-08.2009"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7692"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.03.016"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1836"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.12.020"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805163105"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.112094"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00587.x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20882"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961115)68:4"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3691"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201606042"},{"key":"e_1_2_9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