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To this end, a number of clinical trials are investigating the potential of existing drugs to enhance oligodendrocyte progenitor cell (OPC) differentiation, a process that fails in chronic MS lesions. We previously reported that oligodendroglia express GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptors (GABA\n                    <jats:sub>B<\/jats:sub>\n                    Rs) both in vitro and in vivo\n                    <jats:italic>,<\/jats:italic>\n                    and that GABA\n                    <jats:sub>B<\/jats:sub>\n                    R\u2010mediated signaling enhances OPC differentiation and myelin protein expression in vitro. Our goal here was to evaluate the pro\u2010remyelinating potential of GABA\n                    <jats:sub>B<\/jats:sub>\n                    R agonist baclofen (Bac), a clinically approved drug to treat spasticity in patients with MS. 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