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In this study, we analyzed whether hypoxia\u2010related preconditioning protected Schwann cells (SCs) transplanted into the contused thoracic rat spinal cord. Hypoxic preconditioning was induced in SCs prior to transplantation by exposure to either low oxygen (1% O<jats:sub>2<\/jats:sub>) or pharmacological agents (deferoxamine or adaptaquin). All preconditioning approaches induced hypoxic adaptations, including increased expression of HIF\u20101\u03b1 and its target genes. These adaptations, however, were transient and resolved within 24\u2009h of transplantation. Pharmacological preconditioning attenuated spinal cord oxidative stress and enhanced transplant vascularization, but it did not improve either transplanted cell survival or recovery of sensory or motor function. Together, these experiments show that hypoxia\u2010related preconditioning is ineffective at augmenting either cell survival or the functional outcomes of SC\u2010SCI transplants. They also reveal that the benefits of hypoxia\u2010related adaptations induced by preconditioning for cell transplant therapies are not universal.<\/jats:p>","DOI":"10.1002\/glia.24302","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T13:10:58Z","timestamp":1671887458000},"page":"648-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Temporary induction of hypoxic adaptations by preconditioning fails to enhance Schwann cell transplant survival after spinal cord injury"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-802X","authenticated-orcid":false,"given":"Brian T.","family":"David","sequence":"first","affiliation":[{"name":"Burke Neurological Institute  White Plains New York USA"},{"name":"The Feil Family Brain and Mind Research Institute Weill Cornell Medicine  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-2168","authenticated-orcid":false,"given":"Jessica J.","family":"Curtin","sequence":"additional","affiliation":[{"name":"Burke Neurological Institute  White Plains New York USA"},{"name":"The Feil Family Brain and Mind Research Institute Weill Cornell Medicine  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7525-5986","authenticated-orcid":false,"given":"Jennifer L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Burke Neurological Institute  White Plains New York USA"},{"name":"The Feil Family Brain and Mind Research Institute Weill Cornell Medicine  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1161-2809","authenticated-orcid":false,"given":"Kerri","family":"Scorpio","sequence":"additional","affiliation":[{"name":"Burke Neurological Institute  White Plains New York USA"},{"name":"The Feil Family Brain and Mind Research Institute Weill Cornell Medicine  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5517-3599","authenticated-orcid":false,"given":"Veena","family":"Kandaswamy","sequence":"additional","affiliation":[{"name":"Burke Neurological Institute  White Plains New York USA"},{"name":"The Feil Family Brain and Mind Research Institute Weill Cornell Medicine  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-007X","authenticated-orcid":false,"given":"David J. 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