{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:12:18Z","timestamp":1784146338259,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R25GM095480"],"award-info":[{"award-number":["R25GM095480"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH113780"],"award-info":[{"award-number":["R01MH113780"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32NS082145"],"award-info":[{"award-number":["T32NS082145"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA025128"],"award-info":[{"award-number":["R01AA025128"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012394","name":"Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012394","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Behavioral state plays an important role in determining astroglia Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling. In particular, locomotion\u2010mediated elevated vigilance has been found to trigger norepinephrine\u2010dependent whole cell Ca\n                    <jats:sup>2+<\/jats:sup>\n                    elevations in astroglia throughout the brain. For cerebellar Bergmann glia it has recently been found that locomotion\u2010induced transient Ca\n                    <jats:sup>2+<\/jats:sup>\n                    elevations depend on their \u03b1\n                    <jats:sub>1A<\/jats:sub>\n                    \u2010adrenergic receptors. With increasing availability and implementation of locomotion as behavioral parameter it becomes important to understand the constraints of noradrenergic signaling to astroglia. Here we evaluated the effect of speed, duration and interval of locomotion on Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals in Bergmann glia as well as cerebellar noradrenergic axon terminals. We found almost no dependence on locomotion speed, but following the initial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    transient prolonged locomotion events revealed a steady\u2010state Ca\n                    <jats:sup>2+<\/jats:sup>\n                    elevation. Comparison of time course and recovery of transient Bergmann glia and noradrenergic terminal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dynamics suggested that noradrenergic terminal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    activity determines Bergmann glia Ca\n                    <jats:sup>2+<\/jats:sup>\n                    activation and does not require noradrenergic receptor desensitization to account for attenuation during prolonged locomotion. Further, analyzing the correlation among Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dynamics within regions within the field of observation we found that coordinated activity among noradrenergic terminals accounts for fluctuations of steady\u2010state Bergmann glia Ca\n                    <jats:sup>2+<\/jats:sup>\n                    activity. Together, our findings will help to better understand astroglia Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dynamics during less controlled awake behavior and may guide the identification of behavioral contexts preferably dependent on astroglia Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling.\n                  <\/jats:p>","DOI":"10.1002\/glia.24350","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T08:00:10Z","timestamp":1676448010000},"page":"1451-1465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Constraints of vigilance\u2010dependent noradrenergic signaling to mouse cerebellar Bergmann glia"],"prefix":"10.1002","volume":"71","author":[{"given":"Angelica","family":"Salinas\u2010Birt","sequence":"first","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Center for Biomedical Neuroscience University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice Y.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Center for Biomedical Neuroscience University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryana J.","family":"Cruz Santory","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-3164","authenticated-orcid":false,"given":"Martin","family":"Paukert","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Center for Biomedical Neuroscience University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17062-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2013.09.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23589"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abk1378"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz4232"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2447647"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058827"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.08.052"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-12-07861.1995"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01288.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0679-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.022"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.05.023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.019"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.03.019"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17059-x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.038"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23679"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3464"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13289"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132552699"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1221140"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.07.005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.07.078"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.11.030"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209448109"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(97)90052-X"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63329"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310025111"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19475-5"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0170-4"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.24350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.24350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.24350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:42:32Z","timestamp":1692646952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.24350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/glia.24350"],"URL":"https:\/\/doi.org\/10.1002\/glia.24350","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.06.27.497789","asserted-by":"object"}]},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]},"assertion":[{"value":"2022-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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