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Modified, nonanticoagulant heparins mimic the heparan sulfate glycan family and are known regulators of multiple cellular processes. In vitro studies have demonstrated that low sulfated modified heparin mimetics (LS\u2010mHeps) drive repair after CNS demyelination. Herein, we test LS\u2010mHep7 (an in vitro lead compound) in experimental autoimmune encephalomyelitis (EAE) and cuprizone\u2010induced demyelination. In EAE, LS\u2010mHep7 treatment resulted in faster recovery and rapidly reduced inflammation which was accompanied by restoration of animal weight. LS\u2010mHep7 treatment had no effect on remyelination or on OLIG2 positive oligodendrocyte numbers within the corpus callosum in the cuprizone model. Further in vitro investigation confirmed that LS\u2010mHep7 likely mediates its pro\u2010repair effect in the EAE model by sequestering inflammatory cytokines, such as CCL5 which are upregulated during immune\u2010mediated inflammatory attacks. 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