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However, their ability to differentiate after ischemic injury is poorly understood. The aim of this study was to investigate the properties and functions of NG2 glia in the ischemic brain. Using transgenic mice, we selectively labeled NG2\u2010expressing cells and their progeny in both healthy brain and after focal cerebral ischemia (FCI). Using single\u2010cell RNA sequencing, we classified the labeled glial cells into five distinct subpopulations based on their gene expression patterns. Additionally, we examined the membrane properties of these cells using the patch\u2010clamp technique. Of the identified subpopulations, three were identified as OPCs, whereas the fourth subpopulation had characteristics indicative of cells likely to develop into oligodendrocytes. The fifth subpopulation of NG2 glia showed astrocytic markers and had similarities to neural progenitor cells. Interestingly, this subpopulation was present in both healthy and post\u2010ischemic tissue; however, its gene expression profile changed after ischemia, with increased numbers of genes related to neurogenesis. Immunohistochemical analysis confirmed the temporal expression of neurogenic genes and showed an increased presence of NG2 cells positive for Purkinje cell protein\u20104 at the periphery of the ischemic lesion 12\u2009days after FCI, as well as NeuN\u2010positive NG2 cells 28 and 60\u2009days after injury. These results suggest the potential development of neuron\u2010like cells arising from NG2 glia in the ischemic tissue. Our study provides insights into the plasticity of NG2 glia and their capacity for neurogenesis after stroke.<\/jats:p>","DOI":"10.1002\/glia.24471","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T04:35:33Z","timestamp":1695962133000},"page":"245-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Astrocyte\u2010like subpopulation of\n                    <scp>NG2<\/scp>\n                    glia in the adult mouse cortex exhibits characteristics of neural progenitor cells"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-7065","authenticated-orcid":false,"given":"Lucie","family":"Janeckova","sequence":"first","affiliation":[{"name":"Laboratory of Cell and Developmental Biology Institute of Molecular Genetics of the Czech Academy of Sciences  Prague Czech 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