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Using a murine model of neonatal hypoxic\u2013ischemic encephalopathy (HIE) and confocal microscopy, we characterized the scarring process and examined the recruitment of peripheral immune cells to cortical and hippocampal scars for up to 1\u2009year post\u2010insult. Regional differences in scar formation were observed, including the presence of reticular fibrotic networks in the cortex and perivascular fibrosis in the hippocampus. We identified chemokines with chronically elevated levels in both regions and demonstrated, through a parabiosis\u2010based strategy, the recruitment of lymphocytes, neutrophils, and monocyte\u2010derived macrophages to the scars several weeks after the neonatal insult. After 1\u2009year, however, neutrophils and lymphocytes were absent from the scars. 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