{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:27:14Z","timestamp":1792981634517,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Growing evidence has proven the efficacy of physical exercise in remyelination and motor function performance after spinal cord injury (SCI). However, the molecular mechanisms of treadmill training on myelin repair and functional recovery after SCI have not yet been fully studied. Here, we explored the effect of treadmill training on upregulating peroxisome proliferator\u2010activated receptor gamma coactivator 1 alpha (PGC1\u03b1)\u2010mediated myelin repair and functional recovery in a mouse model of thoracic T10 contusion injury. A 4\u2010week treadmill training scheme was conducted on mice with SCI. The expression levels of oligodendrogenesis\u2010related protein and PGC1\u03b1 were detected by immunofluorescence, RNA fluorescence in situ hybridization and western blotting. Transmission electron microscopy (TEM) was used to observe myelin structure. The Basso Mouse Scale (BMS) and CatWalk automated gait analysis system were used for motor function recovery evaluation. Motor evoked potentials (MEPs) were also identified. In addition, adeno\u2010associated virus (AAV)\u2010mediated PGC1\u03b1 knockdown in OLs was used to further unravel the role of PGC1\u03b1 in exercise\u2010induced remyelination. We found that treadmill training boosts oligodendrocyte precursor cells (OPCs) proliferation, potentiates oligodendrocytes (OLs) maturation, and increases myelin\u2010related protein and myelin sheath thickness, thus impelling myelin repair and hindlimb functional performance as well as the speed and amplitude of nerve conduction after SCI. Additionally, downregulating PGC1\u03b1 through AAV attenuated these positive effects of treadmill training. Collectively, our results suggest that treadmill training enhances remyelination and functional recovery by upregulating PGC1\u03b1, which should provide a step forward in the understanding of the effects of physical exercise on myelin repair.<\/jats:p>","DOI":"10.1002\/glia.24493","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T09:40:36Z","timestamp":1701337236000},"page":"607-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator\u2010activated receptor gamma coactivator 1 alpha"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5180-1372","authenticated-orcid":false,"given":"Hong","family":"Su","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5409-0740","authenticated-orcid":false,"given":"Haodong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-1733","authenticated-orcid":false,"given":"Yunhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2161-3423","authenticated-orcid":false,"given":"Qin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2369-4010","authenticated-orcid":false,"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5722-7159","authenticated-orcid":false,"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burns and Combined Injuries, Department of Special Environment War Wound Prevention and Treatment, Institute of Surgery Research Army Medical Center of PLA  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-3293","authenticated-orcid":false,"given":"Lu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1415-4460","authenticated-orcid":false,"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burns and Combined Injuries, Department of Special Environment War Wound Prevention and Treatment, Institute of Surgery Research Army Medical Center of PLA  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-7569","authenticated-orcid":false,"given":"Ce","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burns and Combined Injuries, Department of Special Environment War Wound Prevention and Treatment, Institute of Surgery Research Army Medical Center of PLA  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-4738","authenticated-orcid":false,"given":"Ying","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-3416","authenticated-orcid":false,"given":"Botao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0092-20.2020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803588"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.12.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.635"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10777"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12281"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3858"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw1888"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21211"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2011-0583"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901149RR"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12614"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05473-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20493"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113853"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(95)90027-6"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2714"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150150502613"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60547-3"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X662408"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.1993.40"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1994.11.433"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01541-3"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2568-14.2015"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1606-1"},{"issue":"8","key":"e_1_2_11_27_1","first-page":"1050","article-title":"Gait analysis using animal models of peripheral nerve and spinal cord injuries","volume":"9","author":"Isvoranu G.","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.060"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119526"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00404"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2015.01.012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0311-05.2005"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.09.016"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.013"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.11.009"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.05.010"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.08.012"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23147"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17-0269"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09614"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094309"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0170-2"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22809"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030652"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0002-12.2012"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23702"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.01.024"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.048512"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1452696"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63934-9.00006-8"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2009.12.141"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7909"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577172"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088215"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968310378510"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00343.2011"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-023-00994-5"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12694"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6595-10.2011"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21262"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1052-y"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.09.008"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1291-11.2011"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.03.015"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.01.019"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-03117-6"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.24493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:34:34Z","timestamp":1705588474000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.24493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/glia.24493"],"URL":"https:\/\/doi.org\/10.1002\/glia.24493","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,30]]},"assertion":[{"value":"2023-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}